Whole genome sequencing

Have any lain done it ? How to manage to keep results secure and private ?

(OP cont.) The threat model being the presence of insurance agencies, employers and other parties who would love to know more about (ways to fuarrrk) you.

You made this thread already once before.

Also very curious about this. You can use a fake name, throwaway email, and use a prepaid card. Send your sample to a friend in another state/country (assuming you have friends) for them to send it to the lab, and don't include a return address. I think the main problem is that if, for example, you and your sibling brought your DNA to a public database, people would be able to tell you are brothers, of course. Now say you committed a crime and your DNA was left on the crime scene. They'll be able to match it with your genome in that database and see anybody even remotely related to it, and how. If even one of them used a real name, address, location, etc., from that point it's pretty easy to be able to match it to your identity. So if you're unsure about your genome's security in your lifetime, I definitely wouldn't tell any relatives about it and give them any ideas. So, we have to make sure nobody besides the genome provider has access to the database, and that it doesn't get breached. This is hard as fuarrrk and probably isn't possible afaik. 23andme is obviously cyberhumped but maybe Nebula? They're partnered with other companies like Longenesis in Hong Kong, which is pretty sketch, but to be fair I'd rather give my DNA to China than Google or glowies. They market themselves as respecting anonymity but it's just a 'promise' in their terms of service which they can change whenever they want, like every other company. Haven't looked into it too hard though.

>>15741 Anyone know of any companies maybe worth using if you follow this?

>>15609 I will definitely do one in the future but they're quite expensive and I would gain nothing without the understanding of the result.

>>15609 The only private solution will be a DIY DNA analysis kit. The Bento Box (https://bento.bio) claimed to be this sort of thing during its fundraising, but it looks like it's released now and focused on non-human DNA. I haven't looked much into it recently. >>15741 > I definitely wouldn't tell any relatives about it and give them any ideas. Doesn't matter. If even one of your blood relatives submitted a DNA sample under their own name, they'll find you. >maybe Nebula Maybe if you're not American, not in a FVEY country, not on a Fourteen Eyes country, and not in a country that has an MLAT with the U.S. Nebula is located in Florida. They're FBI/NSA fodder.

If you have ties to academia that'd be a good solution. I know of labs that will send batches of samples they extract for population genetics studies plus a couple of their own if there are free slots

maybe wait a bit the price of sequencing should come down still, eventually (i hope) we will see reasonably priced desktop sequencers.

>>17314 DYI would be super cool. https://www.labx.com/dna-sequencers I found this random site and I'm not sure what you need but looks like it's maybe $30,000 minimum, which isn't, like, retarded expensive if you really felt you needed it.

>>17313 What do you mean by 'send batches'? I'm assuming some university labs might have mid-tier machines like >>17316 that you can more or less just put your stuff in when they're not otherwise being used, and print your sequence, right? If I was a rich user I would definitely buy one of them and analyze my friends' DNA or random people who wanted to. I'll look into it further but it seems there are lots of consumer-grade devices like the Nanopore MinION, etc. I never thought about just doing it all yourself. There's probably a catch to a lot of them, like they don't analyze as many genes as the labs for companies like 23andme can or somthing like that.

>>17317 last i heard the long-read sequencers (like minION) have high error rates and not enough coverage, so they will give too many false positives if you try to find variants in your own genome. i dont think 23andme does genome sequencing. only snp arrays. its a better long term plan to get your genome properly sequenced, store it yourself, and update the analysis as it gets better in the future.

>>17317 I'll go into a bit more detail about the batches thing. Sorry if I'm a bit vague but I've never been charge of sequencing anything. Basically if the lab doesn't have the infrastructure to sequence samples for a study, they'll send them to a different lab to be sequenced. Usually one of the bigger national labs, at least in my country. These labs will charge a fee for sequencing what you send them. Here's where it's a little vague. I imagine one of two things happens when the researchers send some of their samples to be sequenced. The per-sample fee decreases the more samples you send, so if you are already sending 50 samples for your study it's not a big monetary difference to send 51 instead OR the lab will charge the same fee for sequencing 25-30 samples, so if you have 25 samples to study you can fill the other 5 "slots" with whatever. It's not really rare or shady since worst case you're paying out of pocket, just at a discount.

I am very weary of 23andme and similar sites. I think there should be an open source solution with full transparency and protected by laws like HIPA. Imagine discrimination based on DNA In Lain. Tachibana Labs ""succeeded in analyzing the molecular structure of the genome of human" What exactly does this mean? Has this not been achieved yet?

>>17430 >""succeeded in analyzing the molecular structure of the genome of human" >What exactly does this mean? Has this not been achieved yet? Sounds like a buzzword version of the human genome project. The correct term would be "sequencing" rather than "analyzing the molecular structure". One thing is sequencing, another is understanding what the genome actually codes, how transcripts and proteins interact, etc. IIRC we still don't know what half of all human proteins do. We're still far from understanding all omes https://en.wikipedia.org/wiki/Omics

>>17317 >If I was a rich user I would definitely buy one of them and analyze my friends' DNA or random people who wanted to. Somebody needs to go make the cock.li of gene sequencing: mot guaranteed anonymity but is more word of mouth (though it's kind of blown up by now) than some kind of startup funded by alphabet boys