Shrooms

I have never tried magic mushrooms. Now I'm in Amsterdam and I'm interested in trying those. Any advice for first time user?

Eat a little bit. Wait half an hour. If you feel stange sit down and relax. Thoughts might become repetitive. The radio might seem speak directly to you. Remember you are the master of your self. If you feel scared just take a nap the weirdness will goes away. Otherwise really fun. Enjoy!

take it with orange juice, watch a nature documentary and when you notice something very different, go outside... that's how i typically start. just remember set & setting, if you've packed enough the trip should initiate itself...

Would some Lain with deep mental issues more likely have a bad trip or wind up better from it or just neutral?

>>41322 Depends on shrooms. Some increase neuroplasticity in which case you roll dice rewiring your brain so of course it can get worse / better / neutral.

>>41327 I thought they mostly were all same only a few have more rare psychoactive compounds along side the psilocybin. Im aware of the increase in neuroplasticity but is that only when someone is tripping or does the effect last longer and is it dose dependent?

>>41314 Research heavily on both shroomery and erowid before hand. I pray you have a blessed and healing experience anon.

>>41335 General drug mechanic: Dosage is very important because drugs can bind to multiple different receptors with different binding strength. So if you give very little it will settle on the first receptor with largest binding strength. You take higher dose you fill multiple receptors and that naturally leads to vastly different effects. Natural products like shrooms are a problem because contentration variance is much larger than the dosage window to control what receptors you hit. And with regular drugs you have the issue of supply chain stretching product inconsistent. Labmade artificial corpo drugs aren't good either though because of isomers. Might remember high school chemistry: isomers = same compound but different structure. Nature generally only produces & uses 1 isomer while chem factory will produce all variants and the other variants range from unusable clogging pipeline to harmful. Its also why supplements are often trash, with 4 isomers you are getting 75% unusable so your effective dosage is only 25% but you cant simply increase it 4x to get to 100% either.

>>41342 Unfortunately I never took chemistry in school. Still trying to self learn it some time. Psilocybin mushrooms was put on a miracle discovery fast track drug trial testing. I wonder how long before it becomes legal for medical use since that was a few years ago. The dosages would be more standardized, though they may try using 4-Aco-DMT instead or make up their own psilocin prodrug.