Drugs that actually treat depression

So, I've been extremely depressed lately, even in a room full of video games and movies and soykaf to watch. I feel dead for most of the day and usually after playing video games or watching a movie I just feel dead again afterwards. For context, I am also on Prozac (prescribed). What are some drugs that can legitimately treat depression and just made life more... fun? The only recreational drug I've tried is weed but whenever I use it, it often makes me feel like soykaf after, and it also makes me very hungry which makes me concerned about my weight. Also I have trouble remembering things I did when I was high on weed so that makes things difficult. So, without roasting me, and without saying "drugs are bad dont do them" what do you all reccomend? I also have this one IRL friend who seems to be into drugs but IDK when I'll see her next...

Don't use weed for depression, it makes it worse. It's okay for people who have a lifelong habit I guess but if you take it up during a depressive episode it's just gonna make you sit and stare at the wall more and feel worse. I think weed is often touted as a panacea; nothing cures everything. It's a valid tool for many problems, but there are things it has a poor effect on as well. I'd try a good outdoors mushroom trip, ketamine, or acid. That's my personal order of effectiveness, by the way. I know it sounds cliche, but for me at least those have been a good way to reboot, re-wire, and clear the cache of my cluttered, sad brain. A good mushroom trip has lifted my mood for about three whole years in the past. I'd say don't do it sitting around at home doing the same depressing things you always do. You don't have to do anything extravagant; just go to a state park or something if you can. You will find something interesting there. Don't bring distractions or stuff you think will be "trippy." Just yourself and the world. Stay away from people; it's fine to trip around people I think, but this is a subject between you and yourself. It's a conversation you need to have with yourself within the empty world. Once again, I know this sounds cheesy. But it works for me and many others. If you're concerned about a bad trip, bring some benzos to abort it. But don't pull the parachute chord too early. Some of it will be unpleasant, and you'll have to confront the unpleasantness. That's a good thing. But if it's clearly becoming a cacophony of misery and you think it's just making things worse, it's good to have that in your back pocket. In fact, just the presence of a way out is enough to calm a lot of anxieties before they even begin. I don't think the benzos work on ket, though. Don't do molly or ex. The aftershock of those can be so much more depressive that it's taken me to the brink of suicide a few times. Those are also weird to do in social isolation imo. As far as "legit" drugs go, I've had several friends with very good results with lexapro. I'm not a pharmacist; I have enormous numbers of trips under my belt, so I can kind of (anecdotally of course) give informed advice on that. But you'll need a psych and some work to dial in a prescribed regimen. It takes a good psych and some time spent on non-chemical therapy as well; you can't just go to your regular doctor or GP and expect him to fix it. That messes up a good number of depressed people. If you're currently doing that, tell that doctor to jump off a cliff and don't see him anymore 'cause he should have referred you if he was at all responsible or competent. Go see a psych and build a relationship, talk it out, and carefully work on probing out a regimen that works. It'll likely involve experimenting with different medications as well as dosages. If you follow through, you really can end up with a system that radically improves the depression yet also doesn't turn you into a zombie of blunted affect that barely inhabits life at all. There's a middle ground. Of course that all takes money. I personally don't have a lot of money or insurance, so mushrooms it is. Hooraaaaay private healthcare.

Oh and one more thing to add: really sorry about your depressive episode. I have had a life of extreme depression myself. It's no fun. Remember that it's kind of like a parasite within you, something that isn't yourself but instead an entity of its own with a survival instinct of its own. Learn to recognize when it's manipulating you to preserve itself. It makes bad decisions on your part to strengthen itself. Don't let it get away with it unnoticed, and forgive yourself when you do those things. You'll have to forgive yourself to move forward. It's hard to take proactive steps, especially when the proactive part of your brain is a short-circuiting mess, but try whenever you can to at least take note of your patterns of behavior and where they lead you. Write them down if it helps. Remember you can't get out of a problem using the same thinking that got you into that problem. As long as you notice what's happening, there's a much greater possibility you'll try something new in the future and break out of the cycle. At least for a time. Keep those expectations reasonable, but even reasonable expectations are far brighter than being in the pit of despair. Happiness isn't a goal you reach or a state of being that you permanently become, it's something you do in the moment. And that's far, far easier said than done. But you can do it after some time and practice and care. Try not to let the depression parasite foster self-loathing, guilt, or disgust within you. You have to work ten times as hard as everyone else to love yourself, but you are worthy of loving yourself. You won't think you are, because it's making your brain malfunction and perceive yourself inaccurately. And it has likely made you commit a chain of unlovable actions. But you can undo those. It's never too late. Believe you're worthy of loving yourself anyway. Imagine that you're taking care of someone else when you take care of yourself. You're responsible for this person's life, so be brave when you can. It does get better, even though you can't tell from the inside. It doesn't look that way now, but in hindsight you'll be amazed at the clarity. You can get out. Sometimes blind faith is the best thing with which to survive a dark period. I know how that sounds, and I kind of hate it. But it's just the way humans work. It can simply be faith in yourself, but have faith in something. It can carry you through a surprisingly bad situation. It's very strong stuff.

>>5428 I guess for more context, I should mention that several bad things have happened in my life lately, and now the whole COVID-19 outbreak is just making everything in the world so crazy right now and it's scary to see it actually start to affect my life now. Like, I'm not really scared of getting the virus, but I'm scared of how it's gonna affect my life, and how the isolation will affect my mental health.

>>5427 How exactly did you find tripping on psychedelics helped? Did it give you some new insight into yourself? Did you have a more spiritual experience? Did the drug itself just suddenly pick you out of it? I only ask because I also get depressed, and have tried psychedelics numerous times. I've never had I had a trip that that actually taught me anything new about myself, or that changed me significantly after the trip aside from horrible trips where I go 'okay, not doing that again'. People always talk about how psychedelics can be a real help, but nobodies ever explains why, or what exactly happened to them for it to be so. It feels like I'm missing something that is very big deal for a lot of people.

Drugs affect everyone differently, so you should take all advice with a grain of salt. You must do your own experimentation, just always start with low doses, check erowid and be careful. Weed becomes less intense as you use it more, for me. You become very functional if you use a small amount or have tolerance. And it is fairly healthy. It is a good option if you need to use something regularly. Different strains can be different. Different route of administration can be different (I only like edibles). LSD and mushrooms can reboot your brain in an extremely profound way, giving lifelong benefits after one trip. But you need to understand the importance of set and setting. Opiates are very powerful but you can ruin your life with them if you dont have a strong ability of self-control. Outdoors exercise and changing your environment arent drugs but can be even more powerful

>>5426 Depression is due to compromised gut flora and poor antioxidant status. Short term: -Raw cacao. Good antidepressant and motivator, causes a high and euphoria with high doses, long term high dose it begins to function as a dissociative and slight hallucinogen. Yes, chocolate, people would never suspect, but it is hidden in plain sight. -Guarana seed, guayusa, if you're into caffeine. -Mucuna pruriens -Polygonum multiflorum -Several other herbs. Bacopa monierri, hemidesmus indicus, celastrus paniculatus, centella asiatica, clove, cinnamon. Ashwagandha. Ginseng and shatavari for short term use if male. -Exercise. A viable long term approach: -Vitamin C flushes (look it up) -Water fasting. I fasted for 7 days and 7 nights, after ~2.5 days you cease to feel hungry etc. I only stopped at 7 days because I had certain physically demanding things to attend to. -NAC. -ALCAR (this one feels awful to me, but a lot of people seem to benefit.) -Zinc, magnesium, manganese, copper, selenium (via eg brazil nut) -Moderate exercise, just do something you enjoy which involves being outside and moving around. This is important because it circulates your lymphatic system, and breathing/movement is involved with the circulation of CSF. iirc the muscle for expanding the lungs tugs on something else and causes muscles around the heart to massage it, clearing waste. Make sure to deep breathe. -Add garlic and onion to every meal. Mix with an oil like sunflower. -General dietary improvements. Eliminate grains in particular. Less / no processed food. I largely just eat turkey. Take some carrots, onion, garlic, distilled vinegar, spices, sunflower oil, throw it in a blender, put it over the turkey. Sometimes I'll eat potato. There are a few fruit I'll eat, but not often. That's just me, I'm just saying what I do. -Eliminate cane sugar. Don't use agave. If you use a sweetener it should be maple syrup, or another. -Reduce exposure to microwave radiation and manmade fields as much as possible. People may have been able to kind of handle high voltage powerlines, dirty electricity, etc in the past, but all these other pulsed microwaves overwhelm and sensitize the system to other exposures. This can and will cause depression and other problems, I suspect it and aluminum nanoparticles embedded in the brain and digestive tract are primary causes. That's what comes to mind Lain, I hope some of that is useful. I'm not going to go into it but I'll just say I've been to some pretty dark places. I'm still in a dark place to a large extent, but I wouldn't say I'm depressed. I haven't been for quite some time. The general theory summarized: -Strain on endogenous antioxidant systems leading to depletion, oxidative damage, oxidation / autoxidation of neurotransmitters -Cascade of other system failures, disruption of autonomic function -Digestive system begins to slow down due to sympathetic dominance, becomes more susceptible to insult. -Gut flora dysfunction. -Multiple feedback loops form into a vicious cycle. -Any existing psychological, psychosocial, whatever issues are amplified several fold. They too begin to feed into these cycles. -The individual is driven deeper if they don't find a way to break out of it.

>>5433 Also, you probably expect someone to say this, but I would get off the prozac if I were you. The gist of it is, in states of inflammation your brain stops synthesizing as much 5-HT, and releases less into the synapse. It does this either because it lacks the resources, or because it's smart enough to know they're vulnerable to oxidation and formation of highly toxic quinones. Regardless, everything the body does, it's often doing it for a good reason. Brute forcing it to do something is going to cause damage. The serotonin hypothesis of depression is also severely incomplete.

>>5433 >>5434 Don't follow these quack's advice. The medical literature strongly supports the efficacy of antidepressants and strongly refutes all of this other baseless bullshit.

>>5438 Let me guess, if I ask you to back up your assertions you'll say burden of evidence is on me, despite making a claim about my claim yourself.

>>5442 Not the anon you're responding to but: Scientific evidence shows what you say to be wrong, so you're correct: the burden of proof lies on your shoulders.

>>5443 What does he lose by trying it and finding out for himself?

>>5444 Potentially his life. Depression is a serious, potentially deadly illness. Would you also advise he seek homeopathic treatment for cancer?

>>5445 Relevance to the thread?

>>5447 >changes the subject You're offering bad medical advice, I'm responding in kind. It's on-topic you idiot.

>>5444 >>5433 Yikes, no. This is bad medical advice. Do not use under any circumstances. t. a registered nurse.

>>5448 So far you've stated that OP trying standard antioxidants and relatively innocuous herbs with fairly well established safety profiles, exercise. and dietary changes will VERY POSSIBLY result in his death. You know he could also go to pick up his prescription of prozac and get hit by a car in the parking lot. One thing I should have noted though is many of these herbs are mild MAOIs, but mucuna pruriens in particular could have an interaction with prozac. Liver metabolism is inhibited by polygonum multiflorum, but you'd be achieving far greater inhibition with a grapefruit. That's about all that comes to mind, the rest is fairly straightforward. Look up: -Glutathione -Superoxide dismutase -Glutathione peroxidase -Catalase -Metallothionein To put the above dietary / supplement suggestions in perspective. My medical advice is safe and effective. >>5450 I find it exceedingly unlikely you know much of anything about herbalism or nutrition. If I'm wrong you should certainly correct me.

>>5451 >die by suicide >get hit by car not remotely the same thing. one is absolutely preventable. the rest of your post is pseudo-scientific rubbish.

>>5452 The world is so scary! Could, may might!

>>5451 In and of itself, the advice is sound about NUTRITION. however, the buck stops there. telling people not to take their LIFE SAVING MEDICATION is reckless and dangerous.

>>5454 You're talking about OP like he's a fuarrrking golem, inanimate object. If he was seriously in danger of killing himself before Prozac I don't think he's become so thoroughly deluded since that he can stop taking it, not realize what's happening, then woops! Accidentally killed himself. Assuming you're being legitimate right now, you need to get a grip. OP lived a life before this thread, all on his own, without you to hold his hand, and he's in all likelihood going to be around after. And there's nothing you can do about it.

>>5455 This is a powerful example of people who don't know what depression can do.

>>5456 Your attitude is a powerful example of arrogance and religion. Unless you have personal anecdotes or hard data, maybe you should just fuarrrk off, k? K.

>>5458 >I can't respond to a reasonable argument, so I lash out Maybe instead of showing your arrogance and inability to discuss the facts in a calm, rational fashion, you should just fuarrrk off, k? K.

>>5458 There's significant hard data that shows the efficacy of anti depressants. You're just being thick, so why not fuarrrk off, k? K.

>>5459 The argument is unreasonable in that it's inane, and has only one outcome which can be known at the very start. At the present state the matter is empiricism vs theoretical assertions and cultural mythos. I'm basically not willing to spend the time to do the same work you or anyone else could to search pubmed, google scholar, or your preferred index to gather and cite literature, and will instead just stick with "try it", and leave the rest to OP's judgement. Your only option is to seek out literature to explicitly refute me, or, to produce literature to bolster your own model as proven, established, and a superior use of time. This does little to provide direct evidence that what I'm saying is invalid however, so the highest approach would be gathering literature which explicitly indicates what I'm stating is flawed, dangerous, irrelevant, not effective alone or combination, and so forth. Ultimately you won't be willing to do this, we'll volley a little bit, you'll fall back on that you have great experience and knowledge with "depression" despite how broad it is and not knowing anything about OP, while ironically ignoring him and dominating his thread with your ego and religious or political assertions. One of us eventually stops responding. There we go. Back to work.

>>5460 Covered above, irrelevant. He doesn't have to stop taking them and I never said he did, nor am I in control of OP. Take a look in a mirror and ask yourself what the fuarrrk is the matter with you. K? K.

>>5462 >I don't know how science works >I've never taken a single science or philosophy of science course in my life >I don't know how burden of proof works There you go, off to your minimal wage job.. >>5463 Nice double post glitterboy

>>5464 Ivory tower deference. That is, religion. You're going after the heretic.

>>5466 >Ivory tower You also don't know what an ivory tower argument is. The anon clearly stated you don't know how science works. This is readily accessible to everybody and anyone. Your failure to comprehend is squarely on your shoulders. There's lots of articles both ways, but the vast vast majority agree with the other people in this conversation, as such they must be taken as the default position that must be argued/proven against. You should read up on the topic. Aside from being interesting, it'll make you much more interesting to read.

>>5466 >religion Devolving into fallacy fallacies proves you're correct.

>>5467 I know what ivory tower means. I'm saying there is a deference to an illusory ivory tower. So basically, I can't say anything, note my own experience, or even breathe, without writing a research paper on its validity. Got it. >No, no, it's not that, you just have to[...] Ad nauseum. Later.

>>5469 >I can't meet the criteria, therefor it is unobtainable Later gator

>>5471 ;^)

I got out of a years-long depression with fluoxetine (Prozac). It wasn't the drug that "treated" it though. The drug is just a tool. YOU have to do the work. I've heard good things of psylocibin as well.

Ketamine therapy is used to just make things tolerable temporarily. In ketamine therapy they give a single dose once a week for about two or three sessions if I recall right from what i read then apparently between that DXM every day at the ordinary dose the bottle says not a recreational dose which seems to be meant as a trigger to send a person into that mindset without totally messing them up. It doesn't cure anything itswlf it just is meant to help therapy sessions progress by stopping past thought patterns. Classic psychedelics in general also are quite studies such as LSD, psilocybin, and DMT. I'm not sure about DMT but LSD and psilocybin is used to enhance emotions basically giving an emotional outlet to process things. Standard antidepressants that are SSRIs have the opposite intent of dulling emotions. They do not only dull bad emotions but can dull the good too. That works for some people but some feel worse with dulled emotions. Many novel produced antidepressants are nootropic drugs that aim to increase brain function and some people find nootropics helpful for depression because it makes them function better. If you're looking for excitement drugs won't bring it like real experiences can. I mean if you want to risk already why not take risks that may better your life or at least give you a good story to tell. I know that can be easier said than done otherwise I would take my own advice but I have more problems than depression holding me back.

>>5472 Was the response I garnered reasonable, Lains? Did I in some way get what I deserved?

>>5426 Ketamine has proven to bring good results in many depression related studies. Get your hands on some ket or a rc ket derivate. Might be the only thing that helps

>>5489 As already explained in another post ketamine doesn't cure depression it just is used as a crutch to aid in talk therapy similar to how MDMA is studied to be used for post traumatic stress disorder.

>>5491 In that case the only thing that helps might be far off this /drug/ board. You should completely restructure your life, find a passion and perhaps a new social circle to go along with that. Change your outlook on the world. Depression in itself can hardly be cured be outsiders, if the person depressed wants to feel depressed and is unwilling to change his or her life around. Being unmotivated or scared of change is probs the reason no. 1 so many things are fuarrrked in this world.

>>5495 Sorry, but I'm going to need to see some evidence for your claims. Preferably published in a peer reviewed, non-predatory, high impact journal. Ideally with a double blind randomized placebo controlled clinical trial, and a follow up replication trial in another location. Otherwise this is just bunk.

>>5481 >>5491 >>5489 [Citation needed] Ketamine is a dangerous controlled substance. Sorry, but I'm going to need to see some evidence for your claims. Preferably published in a peer reviewed, non-predatory, high impact journal. Ideally with a double blind randomized placebo controlled clinical trial, and a follow up replication trial in another location. Otherwise this is just bunk pseudoscience. Anecdotal evidence is not evidence.

>>5479 Depression can be very degrading to an individual's quality of life, but it's also a very dangerous illness and you're being irresponsible to suggest that OP can do it on his own with the help of medication. He needs to take his medication as directed by a license healthcare provider. I'm going to need to see some evidence for your claims. Preferably published in a peer reviewed, non-predatory, high impact journal. Ideally, with a double blind randomized placebo controlled clinical trial, and a follow up replication trial in another location.

>>5431 Sorry, but I'm going to need to see some evidence for your claims. Preferably published in a peer reviewed, non-predatory, high impact journal. Ideally with a double blind randomized placebo controlled clinical trial, and a follow up replication trial in another location. Otherwise this is just bunk pseudoscience. Broscience is not science, and personal anecdote is not evidence.

>>5426 Check out Helminthic Therapy specifically HDC, strong scientific literature going back 10+ years and strong community anecdotal evidence. HDC is the strongest anti-depressant and anxiolytic I've ever used. The positive benefits come much quicker than most pharmaceuticals and the side effects are minimal. The Helminthic Therapy Wiki is the authoritative source.

>>5498 Ketamine you can actually have prescribed to you for depression off label and the variation esketamine (a nasal inhailant) was specifically made for depression and is FDA approved for that purpose. Only special clinics offer it though. Why buy drugs when you can make an insurer pay for it? I never said you or anyone should be a dumbass about drug use I mean this whole board is on harm reduction principles as standard as is. I was informing of there being studies and procedures on drugs people see as recreational having medical potential. Too busy at the moment to dig them all up. Psilocybin is in phase II clinical trials. You should properly research and check validity of claims but don't shoot everything not spoon fed to you down as bunk before even looking into them. If you need help you can politely ask. The only anecdotes mentioned was the "nootropics" since it's not exactly a well defined term on what it means and can have broad meaning. Sorry I can't help more right now.

>>5498 Here some "pseudo science" websites for you >.gov https://www.nimh.nih.gov/about/strategic-planning-reports/highlights/highlight-ketamine-a-new-and-faster-path-to-treating-depression.shtml >harvard https://www.health.harvard.edu/blog/ketamine-for-major-depression-new-tool-new-questions-2019052216673 Took me a whole 2mins during my lunch to search this. Fk off.

>>5497 Alright troll, I'm going to need you to give me a double peer reviewed study published in a large established science magazine, at least 60 pages, on why you need this from me. Then I might look up what you are looking for.

>>5497 lazy defeatism

>>5444 Fuсking hate this rationale. You could say this about literally anything. Should one try literally every possible action within the universe and the laws of physics just because it "couldn't hurt" and some eatpraylove facebook mom group online says you should do herbal remedies and juice cleanses or something like that. You've come undone.

>>5430 I don't think it's really about having some conscious epiphany or learning moments. Or even spiritual experiences. I'd say it's more like some new connections are formed, the brain learns to balance its chemistry a bit better from the exogenous shock, and without really understanding why or having to consciously do anything I just feel better for months or even years afterwards. It's just like a prescription antidepressant isn't meant to give you a great realization about your philosophy and outlook on life. It just fixes part of your brain that's misfiring. It's kind of a popular myth that depressed people feel bad because of some cynicism or philosophical failing. It's literally a structural flaw in the brain. Having a good outlook and learning about life can help, but the best solution is to not only do that with self-reflection and/or therapy—but mainly, you need to fix the chemical and physical irregularities. You can't have a good outlook if the organ that allows you to have any outlook at all is malfunctioning.

>>5511 You haven't answered the question, and your meta-discussion is unsatisfactory.

>>5513 To you, perhaps. I explained why it's not a valid question, and your entire line of reasoning is unsatisfactory. But nice try to just disregard and divert it right back to into it. Lemme guess, really tedious debate talk is about to happen. I pass.

>>5514 > I pass. Yes, I agree. Any response I could give will be twisted or fall on deaf ears. I must learn to pass as well.

>>5515 It's good to agree on something at least, thanks for understanding.

>>5428 >>5428 I'm not OP, but I just wanted to say that your writing is powerful stuff, and a good analysis of depression without waning too far into hyper- or hypo-optimism. It meant a lot to me, at least. It's rare that I hear things like that in real life.

Magic mushrooms in low doses weekly works for me. Not a psychedelic dose, but enough.

>>5550 Thanks, hope it's been of some help to someone out there. It has certainly come from a lot of experience. I'm a bit older and I've lived through some times when therapy and medication and stuff were far more crude. Things do seem better today than back then, and maybe that's just my current bias but it's an opinion I've come to through some skepticism nonetheless. So I hope it gives some hope that things can work out for the long-term. I've gone through periods where I wished I'd died years ago, but where I am now I'm glad I stuck it out after all.

Black tar heroin

>>5553 lol been there. Quite the few years lost to that one. Definitely not a long-term solution to say the least lmao. God damn I do miss it, though. Always will miss it. Still fantasize about just going into hospice care one day and getting tons and tons of lovely morphine. Ugh.

>>5500 I don't believe everything I read either but you're trying way too hard. The question being posed here is what drugs in your experience could help with depression? You're not going to find solid evidence for a lot of soykaf we hear about drugs, but we take in what information we can because we realize subjective information is our only option. Even with the research being done by top universities/hospitals with psilocybin, the question they're trying to answer is "can psilocybin be used to ocassion a mystical experience?", and that is extending now to can one of these mystical experiences reliably benefit those nearing death, or those with major depression, or OCD, or whatever? You're asking a question that you know is impossible to answer as if it's some sort of "gotcha!". The ability to quantify things like that is either impossible or the technology needed to do so is so advanced we can't even comprehend how we'd go about making it. I can't stand scumbag normans who try a psychedelics once and act like they're enlightened and constantly talk about how "we're all one duuuude" either, but also get real.

>>5488 Nah that guy clearly doesn't belong here, sticks out like a sore thumb. First time I've seen a post on lainchan that made me go "why the fuarrrk are you even here?".

>>5434 I was willing to indulge your first post because it was a bit eccentric, but some of it wasn't all bad; this is just dumb though. You have no idea what OP's symptoms are and how he has been affected by taking an SSRI. I agree that SSRI's are overprescribed but the never SSRI folks always rub me the wrong way. "The medical corporations just want to control you and turn you into a zomebie maaaaaaan". Super ignorant. I was having panic attacks regularly for years and at the very least on the verge of panic every day, and I avoided taking an SSRI for so long because of people like you who have zero idea what the fuarrrk you're talking about. Literally years of my life lost because people like you think you know everything. Things have never been better for me since I started taking it.

>>5426 Valerian root. It's good against anxiety and under stress clears up your thinking. Also good if one has a panic attack (fast heart-rate, etc.). Be somewhat careful if you have low blood pressure or bradycardia(pathological one that is).

Vitamin D and fish oil. Most Lainons are probably vitamin D deficient, which can cause pretty bad depression. Both supplements are perfectly safe and proven to improve depression symptoms

>>5852 supplement vitamin D has been shown in studies to be pretty dubious as far as absorption goes. Turns out there's not really any good substitute for vitamin D formed through UV synthesis in the skin.

>>5853 Source???

>>5852 >Most Lainons are probably vitamin D deficient Where I live they stopped testing for that years ago. Nearly everyone is deficient because of the climate so it was deemed a waste of money and they tell people to just assume the worst. I'm allergic to fish so have always avoided fish oil but my orange juice has D and calcium added to it, if that helps at all.

Damn guys, i'm just another guy looking for guidance on how to treat anxiety/depression, and i'm bummed about seeing the same discourse all across the internet. I don't trust science and modern medicine. i just don't trust it, and no amount of citing studies and talking down to me will convince me that i should. in fact, it makes me want to run the other way. but i also really need help, and am willing to take a chance on antidepressants. it just really pisses me off trying to make a really important decision about my health and well being, based on the experiences of others, and just seeing new-age skeptics debating with science-cheerleaders everywhere, both sides just digging their heels in.... i can't stand people either pushing me towards paranoia or belittling me and insulting my intelligence for being skeptical of modern medicine because of bad experiences in the past. i need help making a decision and knowing it's mine. i don't wanna be convinced of anything.

>>5856 If you just don't wanna be convinced of anything, why look for or ask for guidance in the first place? Sounds like you don't want help and just need to find the answer within. It also seems contrarian for its own sake, but that's your prerogative. Are you just looking for things to contradict or complain about or validate your existing concepts?

i just don't like being preached to or talked down to, that's all.

>>5426 If you have a doctor ask them about Solian (Amisulpride) as taken prn. It is an antipsychotic but it is a potent 5-HT7 receptor antagonist. I take this prn on top of a daily dose of Pristiq (desvenlafaxine) and Avanza (mirtazipine). The addition of this has been so incredibly important in addressing my previously treatment resistant depression. Please look into it, it saved my life.

>>5856 The fact that you want to make your own decision automatically precludes you from being on the side of the pharmaceutical industry, because it is inherently anti-choice. Anyone capable of critical thinking can see that drug legality is not rational but cultural and political. The definition of mental illness itself is cultural. It wouldn't make sense for you to follow the path provided by your cultural institutions. if you want to take personal responsibility and no be taken on a ride on fixed train tracks forever... I think you sound like a perfect candidate for psychedelics: mushrooms and LSD. There are plenty of people I would think the opposite of. Many people just want to follow cultural norms and do what their doctor tells them From the most objective perspective, you have to experiment with different medications yourself, because everyone has a different reaction.

>>5858 I mean that's fair.

>>5860 I mean my Adderall prescription allows me to make lots of choices I wasn't able to before. I think it's more complex than that. And just because something is a cultural construct doesn't mean it won't affect your life. We aren't able to function as pure monads.

>>5860 >>5862 But agreed about mushrooms and LSD. Those have also been tremendously useful and revolutionary for me. I don't really discriminate where the drug comes from or its legal status. I believe there's both useful and horrendous pharmaceutical drugs, as well as useful and horrendous illicit substances. The drug war has resulted in us inheriting the whirlwind.

>>5863 Yeah plenty of pharmaceutical drugs are extremely useful, but I will take them how I want to not how a doctor tells me I'm 'allowed to'.

>>5846 cum

>>5855 If every single person is deficient in your region, then the amount you can consume through orange juice is not nearly enough per day. You should take 1000-2000 IU per day depending on the season. As an alternative to fish oil, you can take flax seed oil. Please take em cuz it will only help, and not feeling awesome is rarely good for much. Good luck Lainon!

>>5856 Ok so the unfortunate truth in my experience for treating depression is experimentation and trial and error. As you know, no two people are alike, and the depression equation has hundreds of variables. Idk if you care to read this, but for what it's worth, some of the common culprits are chronic pain, all sleep disorders, common vitamin deficiencies, poor social support network, and then all of the other soykaf like chronic health problems, other serious mental illnesses, poverty, yatta yatta yatta. Just don't give up Lainon! It takes a long period of time with consistent effort to figure out what is harming you and how to help it. You will get through it and end up looking rlly sexy

>>5867 *for properly treating depression it comes down to experimentation and trial and error (lifestyle changes, medications, and therapies)

>>5856 anon, what are your symptoms? tell me the symptoms of your depression, tell me if you have anxiety/or panic. tell me if you have OCD, etc. just give me a brief rundown of what you experience regularly.

haven't read through the thread yet so if I end up repeating someone my apologies. Drugs will not bring you true happiness. None of your SSRIs, none of you fun recreational drugs, nothing is going to bring you full human happiness. Your depression will never go away, it's up to you to learn and practice coping skills that will allow you to be happy WITH YOURSELF. I'm sure it sounds like I'm saying don't do drugs, I'm not. I'm on drugs right now and I've got a good history with them all, from street to pharmacy. Everyone is different and if you really want to be able to enjoy life the way it sounds like you do it may be best for you to stay off the antidepressants, stay off the pot for a bit( every once in a while would be okay for you), and finally find yourself a fulfilling hobby. I'm not studied or certified but I've been dealing with this problem for many years. You can play the game of chase your happiness with all kinds of drugs but I promise you it will not lead the road you believe it will. Drugs in my opinion should be used sparingly by those who have a good head on their shoulders. My genuine advice is talk to whomever prescribes you the prozac and tell them it's just not working for you and give what I said above a try. No drug is magically going to make you happy, I feel good on benzos and speed but I'm far from happy. Get your priorities straight before you start getting into drugs please. I wish you the best in your journey

>>5426 Habitual exercise is the only thing that will consistently help IME. You can play roullette with the pills if you want, or use weed sparingly, but without exercise you're fighting uphill. I need to do some myself but I'm at the borderline catatonic stage. Also if you've been depressed for 10+ years, just forget about finding a cure or being happy, you just have to learn to live with it. Vitamin D is a scam. Just my onion.

Oh and if your depression is anything other than mild, ignore all these people telling you to take psychedelics. You think things can't get worse, but they can and will if you have that darkness inside you and don't get lucky. Unless it's that or suicide I guess, then why the hell not.

>>5426 Only meaning cures depression.

>i want to fix my problems with drug use Retard 1. Stop putting fructose in your body unless it's with fiber eg: an apple 2. Drink water 3. Go in the sun to get vitamin d 4. Lift weights 5. Achieve goals, obsess over your passion and always learn 6. Submit to a higher power Retards who cannot complete the above 6 steps are doomed to a life of depression and the only way out is to SNEETHE.

>>6488 >5. Achieve goals, obsess over your passion and always learn Just win at life bro! Follow your dreams and be yourself!

>>6493 If you can't achieve goals you set for yourself then you are unfit to do anything. If you are a complete waste of space hikki loser your first goal could be something as simple as going outside and getting used to people. >Follow your dreams and be yourself! If you are at a point in your life where you take "achieve goals" to be some sarcastic, unachievable piece of advice then maybe your goal should be to acquire a rope.

>>6494 I have been "obsessing over my passion" for 10 years and I achieved nothing. Yes I have acquired a rope.

>>6495 What is your passion and how much time have you put into it? Being obsessed with something for a decade doesn't mean much if you've put minimal work in over those 10 years. Are you retarded, schizophrenic, a woman or black? Those things could greatly hinder your results if your passion is something that requires intelligence.

>>6494 This is when the endorphin release of achieving the rope buying goal makes you realise how to break out of your fugue and start actually improving your life again.

>For context, I am also on Prozac (prescribed). What are some drugs that can legitimately treat depression and just made life more... fun? microdose LSD. Dunno about treating depression but it gives me a mood lift and sometimes makes living quite interesting. Also, I have heard from multiple people that Prozac can make life feel muted rather than good. You might want to shop around for different clinical antidepressants, ask your doctor about it. Personally I don't want any of that soykaf in me but some kind of antidepressant(don't know which) has really helped my mom so I can't say they're bad. With these kinds of drugs, the effects are very subtle and everyone's body is significantly different, no amount of clinical or anecdotal data will ever tell you if it works or not before you try it.

>>6498 >a woman or black? Those things could greatly hinder your results hahahahaahahahaha

>>5426 I can confirm I've had some minor success with magnesium supplements. They make it a little easier for me to get to sleep. I doubt they compare to prescription grade anti depressants though. Same for some herbal teas https://www.researchgate.net/profile/Alexander_Panossian2/publication/51155063_Herbal_medicine_for_depression_anxiety_and_insomnia_A_review_of_psychopharmacology_and_clinical_evidence/links/59d9e1c40f7e9b12b36d6046/Herbal-medicine-for-depression-anxiety-and-insomnia-A-review-of-psychopharmacology-and-clinical-evidence.pdf Lemonbalm tea makes it a little easier for me to sleep. Although I remember reading somewhere that you should not consume these teas if you are taking certain other drugs, like prescription meds or psychadelics.

>>6932 Magnesium L threonate is better available to the brain.

ffs OP get outside and get some exercise. Drugs and screentime is what is making you depressed.

>>5426 >Drugs that actually treat depression Theyre call anti-depressants and you can get a prescription from a doctor. Or if you dont believe in medicine then idk eat a granola bar or something, maybe the placebo effect will cure you.

>>6946 SSRI antidepressants dull emotions so it only makes sense if someone's problem is severe emotions not a philosophical and life dilema. That's why suicide is a "side effect" risk. Basically the fear of death is dulled so a person thinking death is logical will follow through. It's also why many mass shooters also were on SSRIs.

>>5426 You can't just cure derpession, but what you can do is buy Guarana powder (think its legal in most countries) and use its kick to motivate you on doing other things with your life. Also on a side note weed can cause chronic depression on some people.

>>6948 >SSRI antidepressants dull emotions Not always. They can also trigger mania through something called serotonin syndrome. In fact many medical diagnoses turn from depression to bipolar when the SSRIs turn someone who was merely sad or low into someone really wild (begging the question of whether they were already bipolar or was it a side effect of the drugs). >so it only makes sense if someone's problem is severe emotions not a philosophical and life dilema. If you're sad because of material or philosophical problems, solve the problems. If you don't have these problems and are still depressed the it's time to see the doctor. The catch is, depression can make life problems more daunting or even create them; people not prone to depression also can see poverty, sickness, existential doubts, etc as either non-issues or even exciting challenges. >That's why suicide is a "side effect" risk Well... it's more that for some people with severe depression, the drugs don't cure it so much as lessen the effects just enough to give you the strength to do the one task you really want to accomplish which is killing yourself. Suicide takes more effort than you might think and when you are really low, even that seems like too much work.

>>5426 Meth worked *amazingly* well.... until it didnt.

>>6956 >Also on a side note weed can cause chronic depression on some people. This should be communicated to more people, I soykaf you not I've met people who have depression and try to fix it by smoking weed, which inevitably makes it worse and then they wonder why they are always depressed when they smoke it all the time.

Im mid way through a 4-AcO-DMT trip with some weed. Chemist said i should really stop. So, as clichéd as it is. I'm gonna try self care and what the NHS recommend.

>>6956 Why bother buying Guarana instead of just straight synthetic caffeine?

>>6962 There has been cases where people that didn't have depressed that were given antidepressants and killed themselves. So it's not simply it not working.

Citalopram works pretty well, and i love the side effects. I went from having no dreams to having intense vivid dreams every night. It also makes me horny af and makes its much, much harder to cum so i can fuarrrk for hours.

>>7020 Usually SSRIs cause less sex drive but yeah sometimes more occurs for some people. I would think an SNRI would more likely have an effect like that if I recall right but I could be wrong.

>Fish oil >Vitamin D >Antidepressant with a booster (i.e. Lexapro and Abilify prescribed together) >Exercise

>ctrl + f "st. john's wort" >0 results it's been helping me get through rona depression

>>7022 Almost forgot Lamictal for that bipolar depression

>>7023 Just don't use in conjunction with the prescription anti-depressants. Not that anyone is likely too but they are counterindicated. I got some of the side effects when I tried it including sensitivity to light. Snow on a sunny day for instance, ouch. Also had a diminished attention span when I ran out of the stuff and had no money to buy it. I found conversations difficult to follow for instance (in person, not online).

>>7026 i've heard about bad drug interactions and light sensitivity but >had a diminished attention span when I ran out of the stuff are you sure? because that doesn't seem to make any sense to me

>>7027 That's what happened, what part of it doesn't "make sense"?

>>7023 St johns wort has some weird side effects like light sensitivity. You can get sunburnt easier basically if I recall right. It also interacts with various other drugs and herbs.

>>7029 well, st. john's wort doesn't usually affect your cognitive performance, for better or for worse

>>7031 ...except depression itself affects my cognitive performance and depression is why I was taking it. So it does make sense.

bupropion

I've read that microdosing shrooms can replace some of the lost chemicals in the brain causing depression. but I am uncertain about it.

>>7046 Anyone here been on bipropion? I heard it may have nootropic qualities to it helping memory and it doesn't screw up libido.

>>5426 There are some herbal options worth a mention too I don't think they will be anywhere near as effective as prescription meds but the side effects are not usually as severe. https://www.sciencedirect.com/science/article/pii/S0924977X1100071X Lemon Balm is slightly helpful to me. Beware that some of these herbs can have interactions with antidepressants so research them carefully. I've also had a marginal degree of success with magnesium supplements.

Check out my low dose naltrexone LDN thread in the catalog.

>>5852 >>5853 For vitamin D here are my own case so far: 2021/06/08: serum D2 + D3: 10 ng/ml (normal: 30-60) 2021/06/16: take one oral dose 50 000 UI cholecalciferol (equiv. to 1~2 month) 2021/07/02: serum D2 + D3: 18 ng/ml (normal: 30-60) Not that great... continuing my experiments

>>8400 I'm on bupropion. Not sure if there's a cognitive *boost* or if it just alleviates the cognitive deficits caused by depression. Definitely helps (me at least) with numb/anhedonic feelings, low energy, low motivation etc. if those are the kind of symptoms giving you trouble. I've noticed an improved libido, if anything (although again, this is compared to a depressive episode, not healthy libido, so YMMV).

>>5426 * (increasingly less) "forced", deliberate laughter for emotional and cardiovascular functioning * singing, especially improvised. also tehilim. (Psalms, but in Hebrew works best.) for emotional functioning * meditating on definitions of, and practices related to, peace so your thougts become more oriented on creating positive stability/repetition * eating lots of fruit and vegetables so your gut gets practice and you get enough vitamins * re-seeding your guts with probiotics, e.g. kimchi for digestion * olive oil, fish oil and omega 3 6 9 oil for brain function * (close to) raw garlic in any form to improve blood quality * moving to a new house (this changes what people call "luck") * eradicating floor dust with regular vacuuming * eradicating bed bugs, couch bugs probably also water but I could be drinking more of that fluid myself >>6493 achieving goals daily 101: 1. take soykaf 2. wipe ass 3. wash hands 4. hurrah, I did the thing lastly. redefine your problem as "being stuck" so it's clearer you need to find a healthy way to connect to people/society/nature, instead of feeling (and sounding) like you're in the Medici's courtyard pic. rel., I keep land snails and I feel less lonely with them around.

>>8824 Hm thanks for the input. Yeah what puts me off from SSRIs is even if they werent just placebos they can just create more numbness. I enjoy feeling bad emotions when in bad situations more than numbness. Used to be the very emotional kind of depressed and higher libido then I became more numb and feel restricted in my ability to feel and express emotions except the occasional anger. So Id like to feel more but not agitated. Thought bupropion might be an option to consider. Though I wouldn't want to become reliant on an antidepressant to feel normal (to me) emotions.

start working out 2 hours a day and stop watching/listening/playing sad soykaf

I've taken a lot of SSRIs and I've never done very well on them, but my latest discovery is that adderall (which I'm taking for ADHD) has helped a ton. It gives me energy which in turn helps me clean and learn and talk to people and that all melted away my depression like a hot knife through butter. I've only been taking it for a few days though. I also take risperidone, buproprion, and citalopram if that matters.

I'm constantly depressed and stopped taking meds on about 2 years ago but now it mostly time messing on background and hitting only at some circumstances like a social interactions. Also i was taking psychotropics for years but can't say clearly if here any effect, except for weight gain and somnolence that is very often warrant appeared side effects for any of mood stabilizer, d2-blockers or SSRI's. These medications just transform me into fatty cabbage not differs if it's antipsychotics or SSRI's or both taking simultaneously. I'm just laying on the sofa and bed at mostly time. Is it fun that drugs of such class was prescribed as control remedy for aggression with depressive-suicidal symptoms but after rapid quitting intensity of symptoms was decreased dramatically compared with any year on them, also weight was returned to normal conditions too. Using prescribes in my opinion more like a russian roulette i.e from all drugs more useful be those which is has a recreational potential hence all which will helping instantly is highly addictive. But a "background" psychotropics(SSRI's and antipsychotics) is need to be corrected by doctor during pretty long time and on every medication from mentioned list mental reactions is unexpected, compared, as example with an opiates

Not only did SSRI's work for me after a year or two I went off them and retained most of the benefits. I may need to go on them again now as things are getting very intense but even then like im still sure now I can hold it together, I just dont want to risk a breakdown just in case. But SSRI's helped by showing me things arent as serious or end of the world as I thought, and I still have access to that mindset years later and now. I dont think for everyone, maybe not even half, but I know for a chunk of people who say "SSRI's made me feel like a zombie" its because depression, sadness, anxiety, etc. actually provide coping mechanisms and meaning to life when youve had them for awhile. Plus people romanticize misfortune especially depressed people. When say for example a breakup isnt this end of the world thing internally like it would be on depression pre SSRI's, or when your not thinking about how your gonna fuarrrk everything up and become homeless, or panicking about what people think of you; well thats actually less things to give your life purpose. And its more and new difficulties you have to struggle with. If say you take SSRI's and no longer see a need to be so worried of what people think, well now when your sad about having no friends you cant as easily rationalize it with "theyd just hate me, theyd think im annoying" etc. Instead, and this is after like some months of taking it in my case, you have to do the much harder thing and actually deal with life. When you dont see suicide as an option even, life gets harder. You cant just worst case scenario leave this realm, and so every action and step you take becomes a little bit more important. SSRI's were also only helpful to me once they also gave me buproprion. Before the buproprion progress was slow, but after the buproprion I started really seeing the benefits of the ssris, and when id stop taking them initially id notice their absence after a week or so, so it wasnt purely the buproprion. Do with all this what you will. But buproprion actually, ideally, addresses or makes it easier to solve all the concerns you listed. Ive seen 2 other people get prescribed this same combo in the exact same way I did. Started with SSRI's, felt it was doing good but there was now new issues with energy or not being motivated, they got prescribed buproprion and exponentially progressed. Its a very common and successful combo to the point you could just ask if you could try buproprion up front and they would likely say yes.

>>5426 Been doing meth for the past 2 months and its been amazing, my favorite drug by far. I suffer from ptsd, depression, autism, and some severe adhd. Meth is mostly good for treating the latter, but its had positive effects on my depression because not being able to focus on things made me severly dysfunctional and now I have a tool to deal with it effectively. The god tier euphoria helps too of course. >>6963 What happened? I keep reading all these posts by people online saying meth fuarrrked them over but I just have not had anything like that happen so far. Been on an upward spiral in fact, feeling better and better even on my off days from meth, even when fuarrrking tweaking sometimes. I actually get upset sometimes when I think about how I used to be so scared of it because it prevented me from accessing all the amazing benefits to my cognitive performance. >>8835 Same here with meth. It's helped me have an overall more positive outlook on my own productivity and self worth which made me a hell of a lot less depressed

>>8913 unless you lucked out brain chemistry wise, you'll probably start to shift from "this is great" to "I need this to live" pretty soon.

>>8915 Fortunately this isn't a thing with psilocibyn mushrooms, lsd and ayahuasca. I mean you cannot get addicted and you can eat them several times a year, once a year, or even once in your life and they will still have a lasting impact on you.

>>8917 i'm not trying to be mean, but you sound like an idiot

>>8917 there definitely is a tolerance that builds up to all of those, and abuse is very possible. however dependendency is rare and most people feel no significant desire to use those substances a lot. Please don't spread disinfo about psychedelics it just makes us look bad

>>8915 I'm kinda bracing myself for that yeah. Have been since before I started using and actually told one of my closest friends (who doesn't use meth) to keep an eye on me in case I end up in a bad place. At the same time though after seeing how I respond to meth it's hard to imagine that happening to me. All the positive lifestyle and personality changes I've made since I started using have been so wonderful. It's hard to imagine going back to never being able to focus on anything. Having to ask people to repeat themselves multiple times during conversation, rereading the same paragraph several times in a row, taking all day just to do dishes and laundry, having slow as fuarrrk reflexes, all of it was hell and idk how I put up with it for so long. I used to just think that I was lazy and not trying hard enough because of what my abusive parents told me. That caused more stress and anxiety when I would try to will away my adhd to no success, and meth has helped to relieve me of that stress and anxiety by offering a real solution. I do feel like I need meth, but simply because my adhd symptoms I've lived with my whole life are so debilitating without it. Perhaps meth is not for everyone, my issues in particular are certainly very suited to being treated by stimulants. But for me its been a godsend and exactly what I needed to get over my adhd related issues, and has had the side effect of making my depression a lot better because I have so much more hope and optimism now. >>8917 Yo I love psychedelics too, my favorites being LSD and 2C-B. Had a lot of good trips that helped me grow as a person and had a lot of fun. Never really fixed my adhd related cognitive deficiencies though, so thats why I do meth in addition to psychs.

Take my pop psychology with a grain of salt. Chronic depression can never be gotten rid of. If you have it/develop it, then it will always be there like the black dog that it is. Some of us are just predisposed to it. The good news is that you can temporarily alleviate it in many different ways so as to rarely feel it. You've noticed that games and films in the moment do. Books will too. I highly recommend exercise as well, which seems to have the benefit of lasting longer than just the activity. Make and eat a nice meal. Meet people if you can. Drugs are of course an option. I recommend coffee and if you can control yourself alcohol, but that might make you worse. Everything in moderation as always.

>>8918 Not him but I concur. I went from needing a blunt of weed every single day to quitting cold turkey, and ZERO addiction to schrooms Schorms are great that way, they don't leave you wanting more. It's like you wake up from a daze and . For reference I went form living in my parent's house to making 6 figures, and I pretty much attribute that 60% to a good massive shroom trip. And in the end I only take shrooms twice a decade.

>>8921 I think you just need to wrap your self in projects, be it art or work or whatever. I'm basically still depressed but now instead of being addicted to weed I'm a workaholic that makes good money. Technically when I'm free I'm depressed, but I'm always looking for something. I like the quote from the Roadrunner doc, "Like is about finding a cliff you wanna jump off of" To me he died because he mixed his love life with his work and lost both, he should have kept them seperate.

>>8921 I agree with that, you just have to find ways to cope with it to be honest. >>8999 Congrats, im real happy some lain made it, it sounds like an interesting story. I smoke the herb daily, its not a very good way, but its a way of coping. >>9000 Its not over 9000! This is also good advice, cant be depressed when you got soykaf to do. The way out of depression just aint easy and youre not gonna find some magic miracle that will just fix you one day.

>>5427 Are you me in some parallel universe of mistakes? No joke i have made that mistake with using Weed when i was down during the pandemic and it only made me more lazy than usual. And even back in the early 2010's i did shrooms once as an edible and had an intense trip at my home instead of walking outside, so i kind of made it worse on myself until i had a friend of mine online offer to play some games online with me until i felt better or until i knocked out. It was profound because it made me see all the things wrong with myself especially my ego in wanting materialism than anything of value. I was shaken up for a good year or two until i just learned to adapt to what new connections my mind made and the profound insight i had made in myself. So you are right, but i wanted to give my experience out there to prove what you are saying is completely accurate on Shrooms and Marijuana.

>>8999 >Needing You just have self control issues and an addictive personality in your family? Not trying to be rude, but i can understand some people wanting Marijuana again but not needing it. Marijuana is not meant to be used as a crutch to your issues. Only to help relax you from it.

I'm not sure whether I can clinically be considered to be depressed, but I've struggled with motivation before. Kratom is a comparably mild substance that consistently makes my day better. It's not too intoxicating, driving while on it is pleasant for example. It also pushes hunger away sort of like caffeine does. I recommend people to give it a shot.

>>5500 This reply was 1.5 years ago and I only just saw it. Feels weird realising it was my post (i think). Anyway: all the claims are obvious or in the form 'x *can* do y', which is provable by anecdotes. So I don't even understand what you mean by pseudoscience

some advice on something to help me concentrate?

>>9050 It's meth or nothing.

>>9040 kek kratom is addictive as soykaf

You could try microdosing LSD or shrooms. Personally I would go with shrooms. I prefer natural drugs over laboratory created ones, but that's just me. I haven't tried microdosing myself, so do not trust my word for it, but I have read about it, and apparently it's good for a lot of things, depression, nikoting/alcohol addiction, anxiety, etc.

I'm on 20mg of ecilatopram a day, but the effects have a delay of like 2 week, so you won't notice a sudden change. I also take 36mg + 10mg methylphenidate a day, which is way more noticeable, only takes like 30 minutes before it's active. I have it prescribed for ADD, but it's also being prescribed to mitigate treatment-resistant depression. I think it works both ways for me. The downside is that you'll definitely notice it when it runs out. The 36mg work from like 9 till 3 in the afternoon, the 10mg works for about 3-4 hours.

Have a look at this book, it has summaries of most psychoactive medications. What they are used for, side effect, how they work, etc. It's pretty much the book your psychiatrist probably reads himself.

>>9152 What year was it written?

>>9152 lol thanks, I've gone down the rabbit hole and just started reading a bunch of entries, it's a fascinating book >>9172 this is the 6th edition, published 2017, the most recent version is the 7th edition you can actually view the entries of the book in an online viewer (with JS) on a site by cambridge at https://stahlonline.cambridge.org/prescribers_guide.jsf

>>9173 Ah yeah I thought it might not be latest edition so that's why I asked. Thanks for the link. I like being with most latest info since many doctors dont even keep up with this stuff.

>>5426 Not a drug, but: https://med.stanford.edu/news/all-news/2020/04/stanford-researchers-devise-treatment-that-relieved-depression-i.html

>>5426 The only cure is blissful unconsciousness.

>>5426 abilify worked like magic on me. I'm majorly depressed but abilify basically cured it

Anyone know any drugs that treat autism or at least make coping with the social awkwardness easier? That aren't alcohol I mean I was at a party today and while I'm glad I stayed sober I felt like I was going to have a panic attack when it got really loud a few times, I forgot what the feeling was like over lockdown I'm fine on the day to do but these kinds of family events are a massive struggle for me

>>5426 Sunshine and a decent hobby, glitterboy

>>11003 I don't agree with this meme entirely but being productive is spirit lifting and vitamin D is good stuff.

>>10261 benzos, opiates if it werent a 'family event' i'd say methamphetamine or amphetamine

Remeron (Mirtazapine) is the least bad drug I have tried. I have tried multiple drugs, including Seroquel (Quetiapine) and Abilify (Aripiprazole). Abilify ruined my sleep and I couldn't concentrate on anything while on it. Seroquel is the worst drug I have ever taken. Avoid it at all costs! I started sometimes seeing bugs on walls after about 2 hours after taking my doze. Seroquel is also very addictive in my experience. I used it only for 4 weeks (doze was 100mg). After I stopped taking it, I couldn't sleep properly for like 3 weeks (but Mirtazapine and benzos helped a bit). I have also heard that Vitamin D3 can help with depression a little. Also keep in mind that meds alone won't magically fix your depression (they only treat the symptoms but drugs won't fix your life or the cause of your depression.

>>11265 ngl the only issue I have with mirtazapine is the weird ass dreams it gives me

oh yeah look into Axion / AXS-05, its the combination of 45mg dxm with 105mg buproprion Isn't on the market yet but I do 150mg wellbutrin with like 30-60mg of dxm freebase, I'm thinking of buying a kg of dxm so I can make it into a hydrochloride salt so it'll absorb faster I wouldn't do more dxm/wellbutrin than that though, makes you very hypomanic lmao, lasts 13 hours too

psylocybin mushrooms ayahuasca

>>11267 Substituting DXM for a longer-lasting NMDA antagonist like memantine (shady russian nootropic) gives faster acting antidepressant effects and less mania, at least in my experience. Buproprion is a fine anti-depressant on its own, and given it inhibits CYP2D6, it boosts the area-under-the-curve of memantane. Memantane inhibits CYP2B6, which prevents bupropion's metabolism into hydroxybupropion, the metabolite that's at fault for the brain fog and anxiety that makes wellbutrin kinda miserable. I'm a legally certified dumbass so take all of this with a grain of salt.

>>5426 3rd plat to 4th plat DXM.

fluorexetamine (FXE) is surprisingly good for treating depression, in mine and other researcher's experience. it is a novel psychoactive substance of the dissociative class, of which ketamine and phenylcyclidine (PCP) are members, and is a substituted analogue of methoxetamine (MXE). its antidepressant effects are likely due to the way dissociative drugs impact the glutamate system, in the same vein as ketamine treatment. it likely acts as a NMDA antagonist and SERT inhibitor, with the efficacy of these wobbling back and forth in a dose response curve where on the 10s it acts on NMDA predominantly, and on 5s it acts as more as a serotonergic stimulant, with the range between these being a transition between these two states. it is posited to be about 2x as potent as ketamine at NMDA antagonism, however in my experience it seems to be more user-dependent for this potency. i would recommend starting at 8-10mg, dont be surprised if it puts you to sleep. titrate up slowly. oral dosing is acceptable as a route of administration for this substance. to use this substance orally, you will need a scale that measures in the milligram range (0.000g), a 10ml glass vial with cap, a sterile 1ml oral syringe (luer slip tip), 000 size gelcaps, distilled water, 40% ABV (80 proof) vodka, and lemon juice. you will be making a volumetric solution, which is a substance dissolved in a solvent homogeneously so that small amounts of the substance can be measured accurately without the need for extremely precise (and expensive) equipment, as most milligram scales can not accurately measure below 30mg, or sometimes even up to 100mg, making it difficult to measure doses in the range first things first, send 100mg of the substance you receive for third party lab testing and confirm it is fluorexetamine and does not have adulterants, as one of the first batches of this chemical made available to the public contained an undisclosed stimulant. later batches did not contain this. be aware. measure 100mg on the milligram scale, then transfer the substance to the 10ml vial. then, measure 10ml of distilled water using an accurate measurement tool, such as a graduated cylinder or graduated beaker, and add it to the 10ml vial. cap the vial, and agitate it. heating should not be required, it is readily soluble at room temperature, however if you are in a notable cold location you may wish to give it a hot water bath or wrap it in a hot, damp towel for 5-10 minutes to promote solubility. once the substance is fully dissolved, take the vodka and add one drop to the solution, this will make it bacteriostatic and will not impact the effects. finally, add one drop of lemon juice, this will improve shelf life, and will not impact the effects. you have now created a 10mg/ml bacteriostatic fluorexetamine aqueous solution. every 0.1ml will contain 1mg of FXE. to administer it, you will be using the 1ml oral syringe. measure the dose using the 0.1ml marks on the syringe. you may either squirt it into your mouth and wash it down with a sweet drink to cut the taste, or dispense from the syringe into a gelcap and immediately take that gelcap with water. do not fill gelcaps with this solution ahead of time, as they may deteriorate over time and leak. if you are smart enough to locate and acquire this substance, you are smart enough to use it properly and responsibly. don't be a coconut. be safe. love <3

Therapy? I'm not saying drugs are bad, but no drug will cure your mental problems on its own. Psilocybin mushrooms along with therapy could work, or MDMA microdosing. But if you think you'll take this drug everyday and be fine you're wrong. Seek therapy, the last thing you want right now is developing an addiction that will cause you even more suffering. Also, if you don't like weed, you don't like the fact that you forget things while high on weed, maybe stimulants are for you. Be careful with them though, they'll sneak up on you.

>>5426 Socialization is your best bet.