lainchan / drug
Nic high
Undisclosed · 2018-11-17 22:49
recently got a vape and started lunging that soykaf. the body high I get is great. why isn't this more commonly talked about for legal highs?
Agent Smith · 2018-11-17 23:09
>quick entry into bloodstream
>inhaling anything that is not air
its risky, but there is a reason fast acting inhalers exist. I guess a nicotine inhaler would be more effective than a vape
Hacker · 2018-11-18 00:30
it's called getting "domed". Problem is chances of an od are surprisingly high and nic poisoning is not fun.
Mario Rossi · 2018-11-19 05:10
>>2920
link to any proof?
Leto Atreides I · 2018-11-20 03:45
>>2929
https://www.erowid.org/experiences/exp.php?ID=25336
Look through the erowid page on nicotine and eventually you'll see it's not worth it.
https://www.erowid.org/chemicals/nicotine/
Joey · 2018-11-20 04:57
>>2938
apeciated
Drifter · 2018-12-26 19:57
Besides the high addiction rate and needing to care for dosages, are there any physical downsides to nicotine?
Acid Burn · 2018-12-27 01:24
>>2938
A lot of this information is downright wrong. If you trace the studies back far enough, they go to cigarettes.
While the main ingredient in cigarettes is nicotine, it is not the only active ingredient. In fact, nicotine by itself is very non-addictive, but in cigarettes the addiction rate is high.
The best resource I have found on this is the metastudy performed by gwern. It has a lot of academic resources and they are especially good and liberal with their citations and disregard of papers (positive or negative) that do not match best practice in clinical trials:
http://www.gwern.net/Nicotine, specifically: http://www.gwern.net/Nicotine#addictiveness
sage · 2018-12-27 01:44
>>2920
as if other drugs are totally safe
Erik Johansson · 2018-12-27 01:45
>>2919
??
smoke isn't air either... as far as i know, inhaling vapor is easier on lungs than smoke (obviously it's still not that great). but then, you could say negative stuff about any drug, right?
The Phantom Phreak · 2018-12-27 01:54
>>2938
>>3159
Also, with regards to: https://www.erowid.org/experiences/exp.php?ID=25336
this is hilariously stupid
> Now they are supposed to enter your bloodstream over the course of 12 hours, so having seven on is about 12mgs an hour
[...]
> I wasn't scared because I knew the LD50 was something like 81 mgs
7 patches * 12mg = 84mg
lol
Jim Hilger · 2019-01-07 01:26
Goes away very quick until your doing it just to get that relief, which is a high in itself but not comparable to "domed" feeling. Best way i've heard nicotine addiction described is its like drinking a cool glass of water when you are crazy thirsty.
Also a unique thing that happens with vapes is almost everyone I talked to says it eventually makes them lethargic when they are hitting it all the time. Ive known people switch back to cigs because they still are addicted. For me it was a great smoking cessation aid and I only stopped because i'm 20 and 21 is the legal age here and I lost my charger. Plus the pods here although overall cheaper are more expensive to buy at once. Its a lot easier to give a friend a 10 to buy me a pack than dish out a 30 and have to find a store that sells the pods too. The main reason is just lost charger though. I have a juul, I know vapes are much cheaper long term but you can refill the pods with a trick. Still have to buy new ones after a couple uses.
Thats why its probably not talked about though, its not even like weed where people who smoke everyday say they need to to feel "normal". You are smoking at some point instinctually out of a craving similar to a craving for food or water. And also there is kind of a cap to it, so while a stoner can smoke a huge amount here and there to get that super high feeling a nicotine user will get that original feeling after a couple of puffs but then they would have to wait hours until they are craving to get that tiny rush again.
Its unfortunate how much anti vape stuff is being pushed. Its important for people to know nicotine addiction will occur, but trying to say it is or might be as dangerous as tobacco is ridiculous. Many of the questional chemicals are found in near negligible ammounts and also occur in far greater amounts in cigarette smoke. As a cig smoker ive only seen anti vape stuff being an excuse for smokers to continue smoking, ive never seen someone whos never used nicotine say "I would try vaping but....".
Drifter · 2019-01-10 12:05
>>3233
if you are vaping to quit cigs one benefit is it's very easy to taper off with lower nic juice, even to the point of making custom concentrations. then once you're off the nicotine completely it's just a matter of breaking the physical habit if you don't want to keep vaping
it is comparable to cigarettes though like you said, in that you have to keep dosing to stay at your baseline after a certain point.
i try to hit a good middle ground with a high nicotine juice but taking a hit less frequently, so i can keep the feeling of coming up on that slight high
John Titor · 2019-01-11 21:48
>>3160
nicotine is very physically addictive. Much moreso than other "soft" stimulants like caffeine. Just saying, know about the drugs you're taking.
Technician · 2019-01-12 05:03
>>3257
nicotine is not physically addictive.
Demeere · 2019-01-12 05:41
>>3257
Nicotine is not physically addictive (Sorry >>3260, I'm copycatting).
> Le Foll et al 2007, "High Reinforcing Efficacy of Nicotine in Non-Human Primates"
> www.plosone.org/article/info:doi/10.1371/journal.pone.0000230
> Surprisingly, reinforcing effects of nicotine alone have often been difficult to demonstrate directly in controlled laboratory studies with both animals and humans as experimental subjects. Consequently, there has been continuing controversy in the literature about the validity of previous findings of reinforcing effects of nicotine in experimental animals and human subjects [3], [4], [5], [6], [7], [8].
> Guillem et al 2005, "Monoamine Oxidase Inhibition Dramatically Increases the Motivation to Self-Administer Nicotine in Rats"
> http://www.jneurosci.org/content/25/38/8593
> However, nicotine is not the only compound of tobacco. There are >4000 chemical constituents in tobacco smoke, some of which have psychopharmacological effects and thus may contribute to tobacco dependence.
> [...]
> In addition, it has been shown in several species that nicotine has relatively weak reinforcing properties compared with other addictive drugs. Such weak reinforcing property cannot explain by itself the intense addictive properties of tobacco smoking, the difficulty most smokers experience in attempting to quit, and the high relapse rates after quitting (Goldberg et al., 1981; Corrigall and Coen, 1989; Donny et al., 1995; Rose and Corrigall, 1997). There is also considerable individual variability in abuse and frequency of consumption associated with smoking as with other drugs of abuse. In animal models, as in humans, not all rats readily self-administer nicotine, and some aspects of the propensity of the animals to self-administer drugs can be predicted by their locomotor response to novelty (Piazza et al., 1989; Suto et al., 2001).
> [...]
> The present study demonstrates that chronic MAOI treatment enhances the reinforcing effects as well as the motivational properties of nicotine in rats. Indeed, animals pretreated with MAOIs self-administered a higher amount of nicotine (FR5) and worked more to obtain the drug when tested under the PR schedule of reinforcement. In addition, these effects were more prominent in rats selected for high responsiveness to novelty compared with those with low responsiveness.
> [...]
> Together, the present results suggest that, in addition to nicotine, the MAO inhibitory activity of other compounds present in cigarette smoke may combine with nicotine and contribute, at least in part, to the reinforcing properties of tobacco.
Since then animal studies have done nothing but reinforce that the chemical interaction between MOAIs and nicotine is responsible for the high addictiveness of cigarettes, and that nicotine is only barely addictive.
Sorry for the wall of text.