SSRIs and LSD

Is it really true that taking LSD whilst on SSRIs significantly increases the risk of serotonin syndrome? The information I've seen on this is inconclusive, in fact I've seen evidence pointing to the contrary, that it in fact reduces the risk. I'm on a daily dose of 10mg escitalopram (lexapro) at the moment and have access to LSD and I'm wondering if this is a good idea.

From what I can tell serotonin syndrome is mostly a junkie myth, but I still wouldn't mix LSD with anything.

The only real interaction is a substantial decrease in potency of the LSD. However there may be a more likely and dangerous interaction with any drugs from the 25x-NBOMe family, which is the most common type of "fake acid". Make sure to test your tabs.

Don't do drugs if you are on antidepressants or antipsychotics. They both can cause a serotonin syndrome or a neuroleptic malignant syndrome. >>10575 >Is it really true that taking LSD whilst on SSRIs significantly increases the risk of serotonin syndrome? Yes it is. SSRIs mixed with other drugs or meds can also cause a serotonin syndrome. Actually, even SSRIs alone can cause serotonin syndrome but it is rare. Also, neuroleptic malignant syndrome can occur even if you don't use antipsychotics; dopaminergic drugs (in general) can cause a neuroleptic malignant syndrome.

Just to try and out a pin on whether you will or wont get serotonin syndrome. I personally never got it when mixing but, doesn't mean you will be safe. everyone is different and the evidence which isn't anecdotal claims that it is still a risk. Also, mixing cocaine and SSRI's has the potential to cause a brain haemorrhage. Know your drugs and be safe. -ED

Apparently there isn't a clear connection but you need to keep in mind many drugs have secondary effects on other receptors and not all are documented so it's better practice not to mix since certain SSRIs may have other effects. At least have a reduced LSD dose. >>10577 >The only real interaction is a substantial decrease in potency of the LSD. Evidence to contrary. >An alternative explanation is that initial SSRI therapy potentiates the effects of LSD, since acute fluoxetine administration has been shown to increase the LSD-induced suppression of serotonin raphe neuron firing (8). >This suppression normally results in a disinhibition of target neurons in the visual and limbic systems, accounting for the changes in mood and altered visual perception associated with LSD. >Increased inhibition of raphe firing by co-administration of an SSRI with LSD could therefore result in enhanced hallucinogenic effects of LSD due to disinhibition of visual and limbic system neurons. >Thus, the aforementioned individual in the Bonson et al study may have had an increased response to LSD during initial fluoxetine therapy due to a potentiation based on the similar initial effects of both drugs (1). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096346/

>>10576 >in all neurochemistry literature >>junkie myth

>>10584 I'm not saying it doesn't exist, it's just rare and most anecdotes you hear are bullshit

>>10585 >it's just rare It's only rare if you only use a SSRI! If you mix meds or drugs it won't be rare.

In my direct experience, it usually just destroys the trip by taking away the magic. SSRIs also take away subtle but important facets of everyday consciousness while you are on them. Stop taking them, wait 2 months to ensure it is out of your system, then take LSD to deal with the root cause of your problems that lead you to SSRIs. SNRIs are quite likely to be worse and actually lead to serotonin syndrome. The higher the dosage the higher the risk.

>>10588 You have to wean off SSRIs. You cant just stop taking them abruptly or it can cause antidepressant discontinuation syndrome.

>>10592 aka withdrawals post too short postrt too short blahblahblah

>>10592 yes i thought that was so obvious that it didnt need to be stated

friendly reminder that ssris can cause brain damage and the medical heads statement to it is just "its worth the benefits"

>>10595 Brain damage implies neurotoxicity so you're gonna need to post documents. Otherwise the only damage if you want to call it that is a reduction in the number of serotonin receptors due to the upregulation of serotonin. This is how they have their effect. This causes an overall reduced capacity for emotion not just bad but good emotions.

>>10592 yeah you should definitely not stop taking them suddenly, when I was a teenager I got tired of being on zoloft and stopped taking 200mg/day suddenly and had a 2 month long withdrawal that felt similar to a very very bad MDMA crash. Full on brain zaps and emotional volatility that lasted months

my friend took a bunch of mushrooms while on SSRIs and she had to go to the ER for serotonin syndrome, so i think it might be true

>>10585 It's not really as rare as you think. Most people on ssris or doing serotonergic drugs like mdma or even lsd can cause you to have mild to severe symptoms. The only thing is the symptoms only last like 2 days if you can survive that you're generally safe but some might need medical care in those 2 days. Most of the times the symptoms affects during the usage of the drugs so most people just assume they're having a bad trip or that it was all mental but they were actually having serious issues.