Neurogenesis and Sinaptogenesis

Ivan Horvat · 2017-07-03 00:43

General discussion about neurogenic/sinaptogenic drugs and techniques and it's possible effects. List: >NSI-189 >Cerebrolysin (and P-21) >BPC-157 >Dihexa >Apigenin >Cholecalciferol >Lion's Mane >Psilocybin >Harmine >Long term cardio exercise >cranial stimulation >NMDA antagonists (to prevent excitotoxicity) - Memantine Any of you ever used some? Some are simple to find, like Lion's Mane and Apigenin (can be found on chamomile), others can be found on places like Newstar Nootropics and Ceretropic.

Just another Random Lainon · 2017-07-03 11:34

I tried Cerebrolysin several times, doing a standard clinical course of 10 intramuscular injections. Where I live it is used to treat stroke and cerbral hemorrhage, since it improves microcirculation and strengthen vessel walls. Although it did not raise cognitive functions or productivity, headaches were gone entirely (since headache is a spasm of brain blood vessels).

Dujour · 2017-07-18 03:06

>>566 As far as neurogenesis, synaptogenesis, and incresing dendritic arborization goes, your best approach currently is actually removal, not addition. Reduce or eliminate exposure to pulsed microwave and ELF fields (cell phones, wifi, bluetooth, certain batteries, power lines, bad house wiring, etc). They interact with the charge groups that make up the voltage sensing subunit of voltage gated calcium channels, especially those of the L-type, activating them. This leads to chronically increased intracellular Ca2+, upregulation of calcium regulated machinery and transcription factors, which increases activity of iNOS increasing NO in cell states where processing and signalling pathways are too slow to deal with. It then accumulates and reacts with superoxide, ultimately forming peroxynitrite, a potent oxidant. Which damages DNA and other cell structures. Other effects are increased BBB permeability, significant reduction in dendritic arborization and persistently altered morphology, altered neurotransmitter release (VGCCs and calcium signalling is used to coordinate all that), cell death, asynaptic neurons, etc. Not to mention gradually damaging your germ line cell's DNA, and the hippocampal progenitor cells. Etc etc. Etc. This was all known decades ago. The mechanistic approach has finally caught up enough to unravel the underlying means of action. Wireless digital transmission could very possibly be the last mistake the human species will be allowed to make. Soviet, Eastern European, and American research on pulsed and static fields at thermal and subthermal intensities, dating back to the 60's. Compiled by the Navy. http://idisk.mac.com/magda.havas/Public/Military%20Radiowave.pdf Bunch of people with names and credentials that aren't Anon on the Internet. http://www.bioinitiative.org/table-of-contents/ 2 Good reviews: http://www.sciencedirect.com/science/article/pii/S0891061815000599?via%3Dihub https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780531/

Yamaoto Toshi · 2017-07-18 03:26

>>593 With the "what to stop doing to make anything else not a net waste of effort" out of the way, I would suggest cacao. Taken in decent amounts, but in a windowed sense. Not continually. Certain compounds in essential oils of oregano, sweet orange peel, and cinnamon leaf will upregulate BDNF and other growth factors, as well as potentiating newborn neuron survival. Carvacrol appears to be very effective in minimizing brain damage after strokes, edemas, mechanical damage of whatever sort. Caloric restriction promotes neurogenesis. Exercise does as well. Proper diet is quite important. Most food in the world at this point is trash. Organic etc is all marketing half the time and just as shady and unverified as anything else. Caloric restriction is what I'd suggest most. The Indian ascetics, in some way, knew this. I've half starved most of the last decade, and eaten massive amounts of cacao. Not controlling for learned and psychological factors, on the level of the underlying machinery that comprises memory formation and storage, mine seems to be far better than everyone around me. Irritatingly so. I remember everything. I can insert myself in memories and relive them, go through a building only once and be able to walk through it in my mind in near photographic detail. Veritably so, the rate of distortion or omission is very low. My mother has near photographic visual memory, and mine has always been pretty decent, but I attribute a lot to the above. It makes sense pharmacologically. Phenibut of course comes to mind, but I've not found it to augment memory formation much. Most likely the benefits people report are from its action as a calcium channel blocker. Same with magnolia bark, ginseng, etc. What's being done to their calcium channels otherwise? Chronic, and aberrant, activation.

Yuki Nagato · 2017-07-18 12:12

>>567 >headaches were gone entirely (since headache is a spasm of brain blood vessels). That's interesting. Should be investigated. I know psilocybin also works on headaches, as it's a 5HT2A agonist and there's some evidence it also up regulate BDNF. Maybe this hormone has some impact on how headaches work... >>593 >Reduce or eliminate exposure to pulsed microwave and ELF fields I don't think there's enough evidence to say that. Most studies show it's nocebo effect. But... how can one do it (living in a modern society)? Any idea? "Cranial faraday cage"? >significant reduction in dendritic arborization [citation needed] >I would suggest cacao I don't think there's enough evidence for that too. It's know that cacao has MAOI's and help with depression, but not much is know about it's effectiveness on neurogenesis, as far as I know. Also, even if there's some effect, I don't think it's more perceptible than cerebrolysin or NSI-189. >potentiating newborn neuron survival Do you know any drug that does this in a more effective way? I'm looking for something really effective, not these "organic" bullsoykaf. Antioxidants like superoxide dismutase? >Caloric restriction promotes neurogenesis. Exercise does as well. Proper diet is quite important. True. >Organic etc is all marketing Agreed.

Linda Lee · 2017-07-18 15:23

>>596 >I don't think there's enough evidence to say that. Read the papers posted. This was established as far back as the 60's, when it was being investigated as a means of augmenting bone growth (osteoblasts and osteoclasts, again, rich in VGCCs and guided mainly by calcium signalling). Modern day there are FDA approved treatments for depression which, surprise, use pulsed microwave fields. Very similar to the spontaneous (temporary) resolution of clinical depression long noted after 3T MRI exposure. VGCCs control neurotransmitter release. The working memory deficits with chronic exposure however, used to be isolated to people working on towers, or in the room with an MRI machine all day. Now it's the bulk of the human population. Use of pulsed fields is also under active and well documented investigation for the treatment of brain tumors, because again, it increases BBB permeability. So which is it? Are organisms composed of signal transduction pathways that are susceptible to pulsed fields they didn't evolve around, which yield obvious and documented deleterious effects, nearly all of which being completely eliminated by VGCC blockers, or do they just "turn into heat"? People want it both ways. But it just ain't both ways. Nah. The "no evidence for anything than heating" is actually a very new perspective, and obvious bullsoykaf I'm not going to bother engaging with much further. Read the citations above. I understand the psychological resistance, given that you're likely psychologically attached and physically addicted, and have an underlying knowledge that you're powerless and completely trapped. I personally work in it all day long, every day. Have a wifi thing attached to my belt, a bluetooth thing on that. Multiple instances of the same around me. Cell phones everywhere. Work near cell towers. Work near countless cell phones. Radar on half the cars on the interstate. Digital television transmitted over the air. People's smart meters everywhere. And I'm a relatively rural, trapped wageslave. It is far worse in denser population centers, and accepting the truth would be quite crippling. The truth generally neither sets you free, nor makes you happy. Illusions and net delusions are what make happiness for a human being living among other human beings. People's value systems are bizarre hackjobs. soykaf is completely asinine, at all times.

Judge Fang · 2017-07-18 15:44

>>597 >investigation for the treatment of brain tumors, because again, it increases BBB permeability (for chemotherapy compounds that are not soluble, and have no transporters. To get to the tumor.) >>596 >But... how can one do it (living in a modern society)? Any idea? "Cranial faraday cage"? Without proper grounding, faraday cages act like mirrors or antennas, typically worsening the problem. That makes wearable shielding difficult and generally non-viable. I don't believe any of the clothing out there sewn with a silver, tin, or aluminum alloy meshing would actually do much of anything, though I haven't tested. And they might somewhat protect the organs, mast cells, and genitals, but leave the skull uncovered. You really can't. If you're around people, at this point their stupidity, or lack of means to have the knowing, you will be dragged down with them. Painting your house walls with graphite paint just makes any signal that gets through via windows or thin patches, bounce around inside. Obviously anything generated inside would be bad. Static fixtures are therefore not viable unless it's an actual faraday wall around the building. >[citation needed] http://onlinelibrary.wiley.com/doi/10.1111/j.1745-7254.2007.00668.x/full http://www.sciencedirect.com/science/article/pii/S0304394011015473 http://www.sciencedirect.com/science/article/pii/S0006899309025980 http://www.sciencedirect.com/science/article/pii/S000689931001190X https://link.springer.com/article/10.1007/s11011-015-9689-6 I just googled "GSM dendritic arborization" and picked a few out. I've read quite a lot that reported both positive and negative results. What becomes clear is that modulation pattern matters (ie it must be a pulsed field operating on the signalling spec defined for use by an actual device, ie, it is best if an actual device in consumer use is used), there are activity windows and the dose, intensity, and response curve is nonlinear. eg 0.2 microgauss, 0.6 W/kg is not necessarily less active than something higher. And, funding matters. Always.

Netrunner · 2017-07-18 16:04

>>596 >I don't think there's enough evidence for that too. https://www.ncbi.nlm.nih.gov/pubmed/?term=cacao+BDNF Ignore the "superfood" "raw food" movement's stuff, it's muddled and irrelevant. Solid reasoning, the available information and experience to inform an overarching model of how the machinery the universe allows to exist must function, makes it possible to generate models with fairly decent error control despite not directly testing. Cacao is full of magnesium, zinc, and a massive amount of antioxidants. The catechin and epicatechin has been decently researched, theobromine and its upregulation of intracellular cAMP etc is pretty well researched. The phenylethylamine, salsolinol, and anandamide is probably trivial, with a bit of uncertainty on salsolinol's ability to cross the BBB (it does survive first pass processing through the liver in decent amounts). The least researched aspect is likely the quinones formed during fermentation, and the bacterial cultures used. Whether the seeds were roasted. Country of origin, etc. In the space of only a year I've likely consumed more cacao than most people will in their lifetime. It's still mysterious in a number of ways, but I do have a lot of experience with it, and do know how it influences state, state over time relative to X environment, and overall functionality. I don't really have much epistemological troubles in simply assuming it does roughly what I said it does. The means might differ, but the result is the same. Most important though is that there are cumulative negative effects. Its consumption should be in windows, or acute. Not chronic. No more than 3 days per week. And it's also both possible and easy to overdose, which feels horrible indeed. Anyway. At one point I wanted to research cacao. Identify its constituents, etc. That'll probably never happen.

Anamika · 2017-07-18 16:30

>>596 >Do you know any drug that does this in a more effective way? No. I don't know very much about the low level, more fundamental aspects of nutrition and cognition, or certain compounds people supplement. As far as I know it seems neuron survival is mediated by continued use, antioxidant presence, and a lack of excitotoxicity. Which is probably why people report memory improvements with phenibut and magnolia bark. LTP is dependent on proper, orderly, calcium signalling more primarily than GABA. I don't mean to come off like a prick. I'm just really sick of it all. People's behavior grows ever more strange and moronic, and the underlying causes are quickly seeming more mechanical than social, cultural, or even economic. It's been well established that cell phone exposure lowers sperm count, and correlates with DNA damage and morphological malformations. It's known that they damage germ line cells. There is a genetic polymorphism of a gene that encodes VGCCs that causes them to be overractive, causing what is called "Timothy Syndrome". Timothy Syndrome almost universally presents with autism spectrum disorders. At a time when autism rates have risen to 1 in 43 children it is absurd and irrational that this especially would be overlooked. Oh but that's right. All that peer reviewed published literature monitoring calcium flux, and showing an immediate influx of extracellular calcium with pulsed field exposure, then showing it doesn't happen after calcium channel blockers are applied? Guess that doesn't matter. Let's just not make that connection, we're brain damaged anyway. All that stuff with ELF from powerlines in certain prenatal developmental windows, predisposing children to leukemia? Nah, let's not focus on prevention. We'll just make more pretentious commercials about bullsoykaf cancer research that'll never actually get results, while ignoring non-patentable, non-marketable compounds already demonstrated to induce apoptosis in multiple cancerous cell lines. Let's not figure out how to use those at all. fuarrrk it all. Mice put in radio fields that simulate real world human exposure lost the ability to produce viable offpsring after 3 - 4 generations. This is looking like it might be the last mistake we'll be allowed to make. And it might be for the best, there are worse things than death, and there are worse fates than fizzling out or going Mad Max or whatever bullsoykaf it shakes out into.