Anti-Aging DIY

The average life expectancy in my home country is around 78 years for men and 83 years for women. Living longer has long been the norm in industrialized countries. But 78 years is too short for me and many people feel the same way. I would rather prefer 150+. For example, Sam Altman recently invested 180 million dollars in a start-up that promises an extra 10 healthy years, Peter Thiel is investing in "young blood", i.e. blood from young people that is injected into old people to achieve a rejuvenating effect. What are Laion's tips for living longer and healthier? Standard tips are intermittent fasting, exercise, vegetables and a small amount of nuts every day. Will we be able to replicate future therapies based on immunosuppressants ourselves? If so, how complex is that? Are there any interesting studies that show how you can effectively prolong your life?

>>11168 Yeah, you've pretty much got it there. Exercise every day; eat no ultra-processed foods with an emphasis on IF/keto; be in a slightly physically uncomfortable temperature most of the time (bonsai effect); go outside and get some sunshine every day, but not so much as to get skin cancer (this varies depending on your skin pigmentation and local climate); don't drink or smoke; and do not live under constant emotional stress. All of that ought to squeeze an additional 10 years out of your lifespan. Becoming a ghoul or a vampire damns your soul, btw. Don't recommend it.

>>11168 prrevention >>>>> trying to repair damage Simplest hard to follow one is avoid sugar. Sugar causes inflammation which causes all kinds of bad. The alternatives arent better either. Anything sweetener used comes with publications on some negative side effects. Next is stress =aging. You can do the buddhism thing as in if you cant change situation change how you thing about it to avoid stressing over. A linked topic is telomere shortening which are safety caps on your dna. Of corse the superior choice is simply to remove yourself from stressful situations whenever possible.

Thanks for the suggestions. Avoiding emotional stress is currently something I simply do not understand how people do it. Perhaps I am an idiot. I am working as a researcher and have many freedoms, but you always have the pressure to publish or perish. I also did some meditation a while back but I do not see how it actual helps me. Besides another interesting direction I read about is Rapamycin/Sirolimus as an anti-aging drug. But currently they only did trials with mice and fruit flies. The dog experiments are announced since 2016, but nothing is done till date. For the sugar issue, are there some good tricks how to acclimate my taste to "boring" food? I mean everyone of us knows munchies.

>>11168 It's honestly super simple. Eat healthy, work out, build lasting relationships

dont die, have fun. simple as. >>11173 >how to acclimate to 'boring' foods Having less sugar generally acclimates you to having less sugar. Quit as nearly completely as you can for a bit, and then add a little back if you want to at some later time, and itll probably seem to go a good deal farther. And maybe play around with cooking and cooking well, if you're into cooking that is. Food can be good, find some things you like and maybe read some serious cookbook about how to do them correctly, this can make quite a taste difference for all sorts of dishes.

>>11173 After two to three weeks of a ketogenic diet your tastebuds sort of "reset" and everything tastes sweeter. The effect on the palate is like cutting down on salt or quitting smoking. You'll find that the sweetness of a piece of fruit knocks you out and actual sucrose will taste cloyingly awful.

>>11173 You can only reduce stress by living a privileged, good life without struggle. Everyone wants that already.

>>11173 Its not just a matter of amount. Effective digestion is affected by the form. Fruits have sugar but fiber reduces digestion rate. So drinking apple juice is a lot worse than eating an apple. And what you really want to avoid is hfc cause the modified fructose/glucose ratio bypasses the system that's evolutionary used to digest a 1:1 ratio and only measures glucose since that's sufficient when you only encounter 1:1. >>11180 avoidable stress regardless of wealth: Binging bad news and stressing over the evils of the world. Getting mad with high blood pressure over losing in online-games. Had a friend accidentally verify the latter cause they had a heart monitor on him and that thing freaked out when he played games cause he always got incredible mad while losing a match. In general there is a lot where you can do a sanity check and ask yourself is it even worth getting mad over?

>But 78 years is too short for me and many people feel the same way. I would rather prefer 150+. Damb, why tho? Most people seem tired of life by the time they're fifty. Do you want to be one of those freaks that spends every waking moment optimizing their life so they can be as ultra-super-healthy as possible, like that Tom Brady guy? Sounds miserable. Being healthy is nice and all but by the time you hit triple digits you're not gonna be having a good time pretty much no matter what. Go make some memories to reminisce about instead.

>>11182 Till date the only reason I can understand why people become tired of life is the burden of getting older. You are getting more sick, you have more aches and you are slowly simply dying. But besides that if someone would offer me a pill that would life me till the age of 400 with a healthy condition I would pay all my wealth for that. Life has so much to give, there is so much to learn and there will perhaps never be a saturation of what you can see, learn and experience. Thus I want to get as old as possible.

>>11183 sure, but we're not discussing m@gic pi//s that turn you into a 22 year old for f0ur hundred years (which would b great), but practical ways to live a long time. Youll probably be h@ppier as a fit, healthy weight fifty year old than an o b e s e fifty year old, but as far as I know no one has verifiably cracked the 1 hundred thirty mark and th0se who get closest all spend a few decades 3xtr3mely frail. The oldest guy I knew (IDK how old he actually was and by the end neither did he, but it was north of .1K) couldn't remember a lot of things like the names his sisters or m0ther, though he was c0gent enough that this distre55ed him. >>11180 definitely false, stress is mostly about your attitude. There are people with extr3mely comf0rtably lives in material terms who are continually stressed about all sorts of b@nalities, and people with all manner of practical problems who keep a happy outl0ok despite of them.

>>11184 >definitely false, stress is mostly about your attitude. Life is miserable when you do not have enough to eat or a war is going on in your country. Yes you can live with that on better terms if you are looking optimistic in the future. But there is still stress through life threatening insecurities.

>>11186 physiological stress doesn't necessarily cause mental stress.

The leading cause of death is heart disease. Cancer also plays a huge role. Doing the following should increase your lifespan dramatically: >exercise (ideally everything from low to high intensity). both cardio and strength training >eating healthily. avoid processed food and artificial sugar >don't smoke >don't drink alcohol Congratulations you will get much older now. There is always a risk of getting cancer anyway but if you follow the advice above you should be healthier and live longer than 90 percent of the population. You'll also have a better quality of life, look more attractive and be in a better mood and mental health. You can also do stuff like take Vitamin D supplements but these kind of things are just the cherry on top. Take some retinoid cream to look young too. You may be thinking of something more sci-fi. I'm not qualified enough to give you my thoughts on that. Smart people are working on it but there doesn't seem much you can do right now. Medicine and healthtech should get better too. Nice little anecdote: My Dad suffered a stroke. The doctors said his chance of survival were low, and even if he survived there should be some long lasting effects. He recovered incredibly quickly. I believe him being fit and doing all kinds of sports saved his life.

secret tip #1 the body halts growth by inhibiting and reducing stem cell populations, which eventually stops homeostasis and regeneration. solution is to maintain the stem cell populations by reprogramming cells back towards stem cells. gene editing could work, but there are also molecules including naturally occurring ones in food that can also do this. continuous growth (or relatedly, regeneration or reverting to embryonic stages) and hence maintenance of stem cells is why species like trees, lobsters, jellyfish, and hydra all age very slowly / barely. secret tip #2 there is also structural information required. this is provided by function. so you have to use your body and stress it in various ways ie damage it slightly. especially you have to maximize the metabolic efficiency of mitochondria. a combination of fasting and exercise, maybe very low dose of electron transport chain inhibitors. high mitochondrial efficiency is why birds age very slowly (often they got more fertile with age). also applies to neurons, many of which last your entire life and only age due to supporting structures degenerating.

>11192 #1 is blocked by cancer issue and telomere shortening on every cell division. 2# > only age due to supporting structures degenerating very optimistic, common first offenders are alcohol & no sleep doing all-nighters and if unlucky high fever from disease / head hit in accident. That aside you have dna mutation going on everywhere in your body including your head due to an ancestral retrovirus infection that still exists in human genome. So just existing degrades the quality.

>>11188 cause of death determination is a tricky business, but if you can avoid heartattacks and soykaf then sure, you'll be probably better off. >>11186 OK yes probably better not to spend all your time starving (though whether this is better or worse than being obese...idk), but there's a huge number of terribly stressed out / depressed people with all their basic material needs met adequately in countries like the US. maybe we're at war and loosing.

This Lain cares not for life extension but youthfulness. I have been trying to figure the issue of adipose tissue loss in the face. The fat pads whither with age but also I have found they perhaps do so with alcohol and intermittent fasting. I've seen it in my own face and you can see it in Bryan Johnson's face that clearly looks much older now with sunken cheeks. The common factor would be acetone production. Either the acetone itself or a metabolite of it dissolves fat or perhaps it signals the body to burn fat reserves in places it normally doesnt. So how would one reverse this facial fat pad reduction?

I care about this a lot because I had cancer a few years ago and it aged me by a lot WHILE taking away ages 21 to 29 from me. Now I'm 32 and I'm not even gonna live until 80 or 90, I was told I'll probably make it to 60. I hope some of this information ITT actually works. I've been reading that eating Lions Mane mushrooms can be helpful or ones brain. Like a nootroopic. I do not know how true that is. I ordered a bunch of pills of Lions Mane and I've been taking two pills every day. I'll let you folks know if I feel any different.

>>11202 A lot of "anti aging" stuff increases cancer rates while some lower it so you have to be careful. You shouldnt be just taking random herbs willy nilly. Lion's Main is for memory problems, If you dont have memory problems you dont need it and i mention this because long term effects are unclear and i have seen anecdotes of emotional blunting like with other adaptogens. What sort of issues do you have?

>>11203 "Chemo brain" seems like a thing a lot of cancer victims deal with since forever. Plus with my particular cancer it fuarrrks up your cognitive abilities. I feel like I'm trying to push my thoughts through a fog of maple syrup at all times. https://www.youtube.com/watch?v=tSUURvSBR-4 Does it actually do something to your emotions? I don't want to stop loving my family.

>>11204 I haven't personally tried lion's mane and it isnt well studied for that effect so Im not clear how true that is. It likely is dose dependent or down to an effect on certain individuals. It isnt reported anecdotally often as much as with NAC or Ashwaganda and I have taken 600mg NAC near daily for a few months. Though I should mention I had blunted emotions prior for reasons. https://www.reddit.com/r/Nootropics/comments/7mv93h/taking_lions_mane_is_muting_my_emotional_response/ But ive also seen some people say the opposite where they became more emotional. So Im just saying take notice if your emotional range seems off then lower the dose once you notice and see if it improves. What chemo drugs were you on and was it brain cancer or something?

>>11206 Man do NOT fuarrrk with ashwaganda that soykaf like actually turned my emotions straight OFF like I was a robot that soykaf sucked ass do not do ashwagangda.

>>11168 A lot of the ideas and techniques used and promoted for deageing are pseudoscientific at best. The solution to a long healthy life has always been physical exercise, eating healthy, long lasting social relationships. Any extra soykaf is just fluff. There to make a buck off you with the promise of magical shortcuts. But the answer has always been well known. The fact that Brian Johnson (his 1 million rejuvination program) was beaten by Julia Clark Gibson (100 dollar program) really says a lot about how effective a lot of this junk is.

>The fact that Brian Johnson (his 1 million rejuvination program) was beaten by Julia Clark Gibson (100 dollar program) I have no clue who these people are but how can you make such claims? You would need to give them decades of time to see longterm effects and then you still couldnt tell if the individual had good/bad genes or the right idea. And they also might be invalidating their efforts with the stress fighting haters all day. That aside diet has no universal solution. Genetics & gut flora change how you digest food.

>>11210 i think >>11209 refers to biological age and dna tests, in this article: https://fortune.com/well/2023/11/04/longevity-women-biohackers-diet-exercise-bryan-johnson/ she is on place 2 vs johnson (place 6) in this leaderboard: https://rejuvenationolympics.com/leaderboard/ currently the places are different.

>>11209 >Julia beats brian proof is in the pudding, we wont akshully know till their dead if these metrics are gud or bad. Amusingly the ranks include a 15 year old with allegedly the biological age of a 9 year old so idk what to make of this hahah. I wonder whether this wouldn't be better compared to time since peak as opposed to time since birth. Gibson is about 10 years older than Johnson, might make a significant difference. Per year after age 18 johnson's average is higher than gibsons. I think we shall all be fairly impressed if any of these people make it to 115, letalone 150.

>>11209 It is more fringe science not pseudoscience. Basically something in experimental phase. So you could be shortening your life when trying to extend it so it is a gamble.

>>11213 Shenanigans. Science is currently compromised by malice. The wisdom to revert to a common sense mode of living from a few as 100 years ago; i.e. a simple natural food diet, exercise, and maintaining mental health is all that is required to understand. Go outside and watch nature. It is your birthright.

>>11214 This is a stupid argument because someone can do both.

>>11212 i believe 120 is the hard cap due telomere shortening but what everyone really wants regardless is keeping performance up not just breaking a record. If you can make it too 100 while performing like a 20 year old then that would be 100x more valuable than making it to 150 as a living corpse.

>>11216 >If you can make it too 100 while performing like a 20 year old then that would be 100x more valuable than making it to 150 as a living corpse It's plausible we get some ridiculous medical advancements in the medium term from AI and synthetic biology unlocking true immortality. If it pans out then it would be way better to live longer in a decrepit state than less long but youthful, because it increases the probability of getting over the finish line at all, at which point you can just rebuild yourself and fully enjoy the next million years or whatever.

>>11216 >if you can make it to 100 while performing like a 20 year old if you could make it to 60 performing like a 20 year old that would be better than living to 150 as mobile corpse, most likely. But I don't think its unreasonable to assume that if you're like 20 when you're sixty, you'll live longer than if you're like 80 when you're sixty. >>11217 don't maximize the chance of the highly improbable but really nice outcome at the expense of the highly achievable and pretty nice option. >>11213 I'd agree with you if many of the people involved in this weren't overselling it as certain and proven. IDK, some I'm sure are honest, but a lot arent.

>>11218 >highly improbable To me it seems like 50% chance in the next 50 years, 90% chance in the next 1000 years, technology has been accelerating, all it takes is a full model of the mechanisms underlying biology and it can start being engineered instead of guessed at and testing guesses like we've been doing the whole time. It's basically going to happen, just a matter of when and who gets to benefit.

>>11200 So no one here knows of a possible solution to at least partially reverse this? I mean aside from becoming obese which obviously isn't the solution.

>>11219 >all it takes is a full model of the mechanisms underlying biology all you have to do is solve all of medical science. Super easy.

Anyone here have an interest in peptides for anti-aging? Epitalon and GHK-CU seem promising, since epitalon seems to increase telomerase and consequently telomere length, while GHK-Cu seems to upregulate dna repair genes. among other things. Fasting also seems to be beneficial.

>>11219 >all it takes is a full model of the mechanisms underlying biology Consider, for example, the field(s) of technology itself. For a couple of years I did tech support for what I like to refer to as an obnoxiously complex suite of network security products. Someone architected and coded all of them. Innovations notwithstanding, they use many common and documented principles of networking and security. They ran on a customized RHEL; these modifications were known and documented. Similarly, the behaviors and caveats of RHEL itself were more or less known. This OS runs on a processor architecture / instruction set that is known and documented, the logic gates are known, the principles of how something from layer 8 can be encapsulated all the way down to the inputs and outputs of these logic gates are known. The principles of signals and circuits and electronics engineering are known. The physics of electricity is known, semiconduction is known, chemistry of PCBs is known... Despite mak-- I mean, despite the fact that there exists thorough knowledge of the mechanisms underlying the obnoxiously complex suite of network security products, we still manage to routinely encounter unexpected, even seemingly emergent behaviors that pretty regularly result in actual months of debugging and head-scratching by technicians, escalations, TLs, and devs before the answer is discovered. Knowing the underlying mechanisms is likely useful but it by no means closes tickets

>>11223 telomerase shortening has benefits too - its a dead clock that helps curb cancer since the cells suicide through this from their accelerated growth cycle. I suspect if you simply lengthen telomerase universally you might create new issues. Of course there is probably some save area where the improvement is not large enough to block the safety function of it.

>>11224 The difference is, basically whatever you want to fix with computer stuff can in principle be done with enough effort, which is not the case for medicine, where most debugging efforts cannot be conclusively resolved. We're at the level of non-engineers without documentation or command line access trying to do the best they can, so when we break, often no amount of money or expertise will fix you. But we are narrowing in on reverse engineering the system and being able to write arbitrary programs in genetic code and proteins and that is a fundamental shift.

I found something that might be interesting? Apparently hisperidin helps activate the cisd2 gene which is a gene that reduces age related disease and could help skin quality it seems unless i am mistaken. Seems the normal dose considered safe is 500mg daily. https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00838-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807130/ https://examine.com/supplements/hesperidin/

>>11171 >>11172 These 2 comments seems to be the best. Try to prevent yourself from getting diseases or problems by avoiding their causes, then you can live as long as possible

If you want to live a long time in good health, the main things to maintain are good circulation and low levels of inflammation. You'd want to stay slightly cool and not overfed. The right diet and exercise would take care of most of that.

>>11182 Most people are tired at fifty because they get worse/less ability. If you can live 1000 years you won't get exponentially more miserable, you will have highs and lows like any other life. You will lose, but you will gain. Constantly.

I recently tried one of the NMN supplements which some people online claim will rejuvenate you, make you lose weight and bring back color to your hair. On the 1st day I took it, it was highly stimulating, and had too much energy for 2 days. Thought all my problems were solved but after that it actually just makes me tired but increases my blood pressure. I've decided to stop taking it for that last reason, maybe I will try again when the weather is warmer and I'm less prome to blood pressure issues. I bought mine from Renue by Science. Also, recently heard about IV 3000 to regrow fingers. Pic related.

>>12148 >regrow fingers What.

>>12148 > On the 1st day I took it, it was highly stimulating, and had too much energy for 2 days. Thought all my problems were solved but after that it actually just makes me tired but increases my blood pressure. I've decided to stop taking it for that last reason, maybe I will try again when the weather is warmer and I'm less prome to blood pressure issues. Have you tried just ordinary niacin? >IV 3000 >regrow fingers The fuarrrk is this stuff. It isnt a search friendly term. I am getting results for catheters.

>>12148 No eait never mind spoke too soon. You already can regenerate your finger tips. It is only part of your body that regrows. Iv 3000 is just a special wound dressing and sometimes some artificial dermis is used. It just helps speed up recovery. No anti aging tech rather speedier wound recovery. https://pmc.ncbi.nlm.nih.gov/articles/PMC5147282/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11242295/

The various research papers I know of about long and healthy life expectancy indicate the following can help: -Mediterranean diet -regular exercise -caloric restriction -cool environment -coffee and tea drinking -anything that reduces overall inflammation -anything that enhances good circulation

>>12154 I've seen others suggest that caloric restriction might actually be iron not building up as the real cause. Coffee is only supposedly good in some studies, seemingly only paper filtered, French press is bad, something about the oils may be a cancer risk. Keeping away advanced glycation end products seems to be a big one which you can manage with your diet but it's a hard one since it is in meats and high temperature cooked foods but you can also help reduce the absoption with vitamin c, quercetin, carnosine to name a few. Finding ways to reduce interleukin-11 is a big possible one too https://www.nature.com/articles/s41586-024-07701-9

>Chaga mushroom >Lions Mane mushroom >Green tea >herbal teas (find the good ones) >Cannabis edibles (low doses) >exercise >vitamins

The consensus of the major studies I've seen is that coffee consumption is associated with longer life expectancy. "Higher coffee consumption associated with lower risk of death" https://www.escardio.org/The-ESC/Press-Office/Press-releases/higher-coffee-consumption-associated-with-lower-risk-of-death "Coffee drinking was associated with reduced risk for death from various causes." https://www.acpjournals.org/doi/10.7326/M16-2945 "In conclusion, this study suggests that the moderate consumption of coffee, particularly caffeinated coffee (range 1–6.5 cups per day), is associated with a lower all-cause and cancer mortality after a long follow-up period." https://pmc.ncbi.nlm.nih.gov/articles/PMC8070495/ "Coffee...joins the Mediterranean diet as being among those dietary components that extend life, protect against neurological and liver diseases, and protect against the diseases of other organs." https://pmc.ncbi.nlm.nih.gov/articles/PMC9916720/

>>12156 Good list. And the most important one: QUIT DRINKING ALCOHOL

here is a simple idea (unproven, but plausible) keep your body cold, every animal that lives in coldness lives long, sharks, sponges, star fish.

>>12169 In a study done with monkeys that were kept in a cool environment for years and compared with similar monkeys kept in a warmer environment over the same period., the monkeys kept in cooler conditions showed much less effects of aging.

>>12159 I find coffee difficult to consume due to health conditions (anxiety). So those who consume it will be more likely to be anxiety-free. This provides at least one reason why it may not be causative. I'd expect likewise with people that struggle with sleep or have heart conditions.

>>12184 unless you're taking a huge amount I think thats a very weak effect compared to other life choices. >>12180 doesnt AC also increase schoolchildren's measured IQ (while the AC is on anyway) >>12169 the cryofreezernatics take this to the logical extreme, but I dont think any have woken up yet >>12161 lol so many old people drink plenty and have their whole lives this isnt a big deal maybe matters different for different races, indians probably shouldnt be drinking just in general

>>12185 Cope harder. There also are centurions who smoked but that doesn't mean smoking is good for you. I drink and I can say alcohol is one of the contributors to AGEs and it also produces acetone in your body which I suspect possibly causes facial fat loss leading to a sunken appearance. It also is a carcinogen. https://academic.oup.com/alcalc/article-abstract/39/4/316/139292 https://pmc.ncbi.nlm.nih.gov/articles/PMC5372728/ https://www.ncbi.nlm.nih.gov/books/NBK606507/

https://raypeat.com/ >This website currently reports on my research in aging, nutrition, and hormones. You will find this information in the ARTICLES section. >A variety of health problems are examined (eg., infertility, epilepsy, dementia, diabetes, premenstrual syndrome, arthritis, menopause), and the therapeutic uses of progesterone, pregnenolone, thyroid, and coconut oil are frequently discussed. >My approach gives priority to environmental influences on development, regenerative processes, and an evolutionary perspective. When biophysics, biochemistry, and physiology are worked into a comprehensive view of the organism, it appears that the degenerative processes are caused by defects in our environment.

>>12189 That website reeks of quackery. But by all means, drink plenty of coconut oil if you think it will improve your health. Lol.

>>12187 I'd hardly have taken issue with your post if you didn't call abstinence from alcohol "the most important [thing to do to prevent aging]". Sure maybe its a good thing to do but its hardly the most important. Not sure personally what the most important _is_ but if I had to make a suggestion it'd be something along the lines of maintaining a healthy weight and body composition. Very few obese centurions, or centenarians either for that matter.

>>12195 I'm a different Lain, not who wrote the post, so my response wasn't personal. What I am most unsure of is if alcohol is worse as sugar or is sugar worse or are they about the same. They kind of are related in a way seeing that sugar can be converted to alcohol and both can be involved in AGEs. Though there is many other sources of AGEs including certain meats. Trying to have optimum health sure can be stressful and keeping stress down is part of having good health, fuarrrk.

>>11168 Have a felt purpose and execute on it with success every day. >>12194 https://recipeats.org/obese-lawyer-special/

>>12195 just the damage to your sleep that alcohol does makes it one of the most important things to cut out or harshly limit

Obviously the way to live a long life is to eat a diet of animal foods, avoid consuming plant matter and avoid stress as much as possible.

>>12198 thats absurd alcohol (in moderation) doesn't effect my sleep in any discernable way at all

just don't eat soykaf, exercise, take care of yourself, pay attention to ingredients and avoid carcinogens

>>12258 good advice, but this implictly means eating a zero carb, raw meat diet.

>>12362 Humans evolved around cooking food. Raw meat for humans doesnt really make sense especially when restricting either protein or iron is possibly considered to lengthen lifespan.

>>12363 >Humans evolved around cooking food not true , meme >Raw meat for humans doesnt really make sense not true, since there are more nutrients and no carcinogens, no advanced glycation end products(as well as the compounds which prevent the production of such things) >especially when restricting either protein or iron is possibly considered to lengthen lifespan. Not true. High protein in the context of low carbohydrate(and low insulin) is not the same as high protein in the context of high carbohydrate(which increases insulin and IGF-1). On a ketogenic diet, your IGF-1 will be lowered compared to a typical diet.

>>12364 seriously though, I don't understand how people still believe the "humans evolved to eat cooked food" meme when humans have some of the lowest stomach acid in the animal kingdom, on par with many scavenger animals, and more acidic than obligate carnivores. A healthy humans stomach acid is 1000 times more acidic than a dogs, and 100 times more acidic than a cats. We are not evolved to eat cooked meat.

>>12362 >>12364 >>12365 Enjoy your tapeworms you fuarrrking retards

>>11168 >[corporate wannabee] convinced [clueless investors] to invest [random number] millions into [phony tech that break the laws of physics] You have already seen this pattern and you will see it again. Learn to accept death, plan your life ahead, know what to expect for each decades and do the best you can from your time. >What are Laion's tips for living longer and healthier? Healthy food (diversity is key) and lifestyle. A bit of sport and go to bead early everyday. Wanna live fast? Okay, do, but don't complain that you arrived first.

>>12366 this is also dumb, since tapeworms usually require a source of carbohydrate to develop.

>>12366 ringworms have anti-inflamatory action and were under study for diabetes treatment before the chinese cured it.

>exercise I don't know why people think that exercising will somehow lengthen your lifespan, when exercise is literally stress for you body and stress ages you. Just look at the faces of people who have been exercising a lot for years and you will see that they look way older than they should be. Also do you think that humans in the past exercised? Look at the tribes that are still alive today, they dont go around picking up heavy objects and putting them back down like modern humans do. And no other animal does either. Obviously you need some movement, otherwise you muscles would atrophy, but you dont need exercise for that, proper diet and some light movement is enough.

>>12435 It depends on the kind of exercise. Something like long distance running is terrible for your body and ages the face horrendously.

>>12435 I've exercised in miscellaneous forms so typically throughout my life it's pretty much become an unconscious habit and it's benefits seem obvious, to the extent I forget some people can be so uninitiated. I think this guide put it nicely: https://liamrosen.com/fitness.html#exercise >Lifting weights makes you stronger and healthier, improves your posture, makes you less injury prone, and strengthens your bones (making it especially important for the elderly and for women). Additionally, it speeds up your metabolism even while you rest - more than cardio by itself. >Cardio is good for everyone because it improves your overall endurance and ability to exert yourself over an extended period. It promotes cardiovascular health and contributes to increased bone density. Additionally, it pretty much makes everything else function better: cardio helps stabilize hormone levels (increasing testosterone and increasing insulin sensitivity), improves endurance and recovery, helps the body fuel calories away from the fat cells and into the muscle, helps with weight maintenance/preventing the "yo-yo effect", generally keeps you healthy, and finally burns calories. Pretty much every claim there is linked to a scientific citation. As others in this thread have put it, the key to living long is staying healthy, and exercise is healthy. >Obviously you need some movement, otherwise you muscles would atrophy I agree completely, this type of movement is known as exercise. As with anything, it's possible to overdo it, but most people in the developed world underdo it.

caloric restriction seems to increase the lifespan of all animals.

>>12440 My point was that exercise is stress and when you want to live as long as possible, you want to minimize stress as much as possible. Of course diet is another factor, but we are talking about exercise here. >I've exercised in miscellaneous forms so typically throughout my life it's pretty much become an unconscious habit and it's benefits seem obvious, to the extent I forget some people can be so uninitiated. Do you feel good when you exercise? And I mean DURING exercise, not after, because when you look at people exercising, their faces seem to point to them not enjoying it too much in the moment, they look like they are in pain and just discomfort in general. Of course after you are done, your body releases endorphins to reward you for getting out of the stressful situation, except in this case, the stressful situation is totally self inflicted. Think about what you are doing when you exercise, you are forcing your body to undergo extreme stress when you clearly don't want to. But i guess that is what people call "discipline". >Lifting weights makes you stronger and healthier, improves your posture, makes you less injury prone, and strengthens your bones (making it especially important for the elderly and for women). Additionally, it speeds up your metabolism even while you rest - more than cardio by itself. This is literally your body adapting to the stress you put it through. That does not mean that it is a good thing. By doing cardio, your heart will literally enlarge, which is why your resting heart rate goes down, since your heart can pump more blood with each beat, but an enlarged heart is not a good thing. Also having too much muscle will put a lot of strain on your heart which can again lead to heart issues. As for making you injury prone and strenghtening your bones, that is not an issue if you eat properly. Of course these days the majority of humans dont eat properly and as a result they are more prone to injuries and they have weak bones. >Cardio is good for everyone because it improves your overall endurance and ability to exert yourself over an extended period. It promotes cardiovascular health and contributes to increased bone density. Additionally, it pretty much makes everything else function better: cardio helps stabilize hormone levels (increasing testosterone and increasing insulin sensitivity), improves endurance and recovery, helps the body fuel calories away from the fat cells and into the muscle, helps with weight maintenance/preventing the "yo-yo effect", generally keeps you healthy, and finally burns calories. Again, just your body adapting to the stress. As for hormones, just unironically cholesterolmaxx, since cholesterol is what your hormones are made out of. Your body will produce as much of each hormone as it needs to, as long as it has enough cholesterol. And before you say it, cholestrol does not clog your arteries, rather it is seeds oils that do that. And exercise does not increase testosterone in the long term. While your body does spike testosterone right after you finish exercising, that testosterone is quickly used up to repair the damage you did while exercising. If you truly want to increase testosterone, eating plenty of animal fat is the way to go. You could also eat brain, which would be the best, but getting brain from a healthy animal is not easy these days. As for weight gain/loss, that is all about hormones, if you stimulate insulin (by eating carbohydrates), you will gain weight. If you stimulate glucagon (by eating meat and animal fat), you will lose weight. >calories Your body does not care about calories. It is about hormones. You could be eating pounds of butter each day and as long as that would be the only thing you would eat, you would lose weight, assuming you were overweight in the beginning. However the moment you would start eating carbohydrates alongside the butter, you would gain weight. >exercise is healthy I don't see how stress is healthy. Now obviously being a fat slob is not healthy, but that can again be remedied by eating properly. In fact, you don't even need to exercise and as long as you eat properly, your body will put on muscle and get rid of any excess bodyfat. >I agree completely, this type of movement is known as exercise. What I meant by light movement was going on a walk, not exercise. Exercise is way more stressful than going for a walk. Again, no humans in the past exercised, in fact, not even tribes that still exist today exercise and they are healthier than most humans these days. The ideal human physique is lean with a natural amount of muscle, easily achived by eating properly and some LIGHT movement.

As a general practitioner I get to see people age and see different people with different lifestyles. What I learned from that, regarding aging healthily and or getting old in order of importance. Don’t be overweight. This can not be overstressed. Being overweight makes healthy aging next to impossible. Your body gets weaker, it will not be able to carry that weight literally. A slim old person can move perfectly fine even if the joints start failing the muscles start weakening. There are a multitude of diseases that come with being fat I don't need to mention all here. Being slim, not just not overweight, will drastically make you age better. Absolutely don’t smoke. If you do, your magic anti aging pill is stopping. Smokers age badly. Mental illness makes people age extremely badly. They get ill more often, die earlier and age visibly faster. Medicine for mental illness can help depending on what issues you face, but only very little sadly. You need to fix those issues not drown the symptoms with medication. That’s what I gathered from my years of treating a hundred patients a day.

>>12443 You, sir, were the last straw that made me decide to stop eating like a pig.

>>11168 you could always try estrogen that soykaf really seems to work

>>12455 Unless you take Raloxifene along with it that may cause breast growth, possibly. Lower doses of estrogen that may not happen but there may be mild effect. Also kind of a mixed bag since some people it may make their cheeks look fuller and it also makes skin softer and smoother but others may look more sagging jowl like which doesnt look youthful. Only possible way around that would be topical application in specific locations, it will spread but this may slightly reduce fat accumulation in undesired places or loss in undesired places but im not sure. Also OP was talking lifespan extension more than looks, there was another thread some time ago focused more on youthful looks but it didnt get as much attention.

>>12442 t. picrel surprised he still have people beliving him. textbook /fit/ meme

>>11168 >don't drink alcohol or smoke >cleanser, moisturizer, sunscreen and tretinoin >keep yourself hydrated, most people don't drink enough water >become estrogen dominant to age better and live some extra years >get bloodwork done once a year to make sure you have ideal levels of everything >keep yourself active and in a healthy bmi, walking to everywhere you have to go that takes you an hour or less can be enough if you have to go outside often, otherwise pick up a sport

>>12961 I wish I decades back had a hormone screening. I am not sure if my hormones changed and even if I checked I'd have no way to know if they did and if I do better with higher or lower testosterone and estrogen. Since everyone can be different I can't just go by what some doctor says based on some arbitrary numbers of averages especially if they push it based on nothing but my sex and age. Hormone receptor sensitivity is one factor to take into account.

>>12962 Unless you have some weird estrogen insensitivity disorder or something high E and as low as possible T is better for looks and lifespan, assuming you don't care about the tits or can cut them off

>>12457 Goatis is a hypocrite who obviously just panders to his audience for NEETbux through soykafcoin donations. There are countless instances where he went back on his ideas and opinions just because his audience stopped giving him money. If you had any critical forethought you would understand that he doesn't live the kind of life he espouses.

>>12963 Im not sure on that being right. Since there is pros and cons to both estrogen and testosterone. One would have to target specific areas. Also there are non feminizing forms of estrogen if you actually think it would expand your lifespan which i personally dont care about currently.

>>12965 It expands lifespan as opposed to testosterone, technically being an eunuch would work too for lifespan but without any sex hormone in the body you'd be like a menopausal woman

>>12966 The way you describe hormones sounds like you either don't understand them or are using overly vague language. Females have more testosterone in them than estrogen, same as males, it's just a different ratio. Having both low testosterone and low estrogen I don't know. Has there been cases of this? I know there is medical conditions where people never hit puberty naturally so has there been studies on their lifespan? Also I would think the advantage would be lost once older having already hit puberty long ago.

> Exercise, both cardio and muscle training *CARDIO IS VERY IMPORTANT* > Sleep good, at least 8-9 hours > Have good sex > Cook meals, eat 1/2 veggies 1/2 meat > hydrate yourself i've learned this from my ex who was 29 and looked 19 > eat a lot of colagen and vitamin C works good for me at 29 i have a perfect skin

one thing that can help as you get older is to make sure you're getting enough choline in your diet. it's necessary for good brain function and good muscle function, and your body needs a lot of it. by far the two best sources are egg yolks and liver. there's also a lot of vitamin b-12 in liver, not to mention a huge amount of vitamin a. braunschweiger (liverwurst) has a lot of choline, too.

I wouldn't want to extend my life if I am not going to just look 20 forever. There has to be more than just basic skincare for improving a youthful appearance.

Geopeptides sells all kinds of things for anti-aging. I got my ghrp 6 from there.

>>11171 >>11172 These two comments seems to be the worst, written by absolutely deranged people. Sugar has lots of benefits! Most of sugar issues are actually caused by PUFA (diabetes for example) Better consume it from fruits and honey Exercise/fasting/keto can wreck you really bad. Please, be extremely cautious with that soykaf. These three are stress-inducing activities and stress is death. Don't age yourself for no reason. If something feels bad, it probably IS bad for you. In general, walk and talk is the superior physical activity. You should always aim to speed up your metabolism, not slow it down. Metabolism is life! Warmth is life, cold is death. Faster metabolism = higher body temperature

>>12963 https://raypeat.com/articles/aging/aging-estrogen-progesterone.shtml

>>12442 high iq post right here

>>13157 Don't fall into the trap of reading one thing and thinking it explains everything. Saturated fats are the devil! No, sugar is devil!, No Polyunsaturated fats are evil! And so on. Avoiding PUFAs is a proxy for avoiding very processed oxidized foods. Eating some nuts or a bit of fresh sunflower oil isn't going to destroy your body. Its the rancid and oxidized oils that are reused for frying everything that clog up your cells metabolic pathways. Same with sugar. Nothing wrong with fruit or cane sugar. Its when the sugar is put in high amounts into every meal where can't taste just how much there is. It keeps your blood sugar constantly high and the normal insulin regulation stops working. (Constant high sugar triggers pancreatic beta cell death as a side effect of how they are regulated.) Similar with stress. You don't see pro-athletes being long-lived. But lazy people are not very healthy either. The important part is having enough rest time between exercise or acute stress that the body can repair and adapt. Ray Peat makes some interesting observations, but his main appeal is that he emphasizes self-experimentation and observation rather than taking some poorly executed papers about diet as the truth. He was not unhealthy but not super healthy either nor lived a particularly long time. Just a regular dude drinking his coke (without high fructose corn syrup) and eating bacon refried in coconut oil.

>>13157 Name a benefit of sugar then. Its simple fact that sugar causes inflammation and chronic inflammation causes disease. You dont need to be 0g sugar but typical american diet is way over the limit.

>>13163 (not him) its calories you need calories a lot of the time the alternative is all of these fishy random non sugar sweeteners which aren't clearly good for you and are mostly just stuck everywhere because people want empty junk food inflammation isn't entirely detrimental either

>>13161 All truth. I agree. I can't tolerate seeing soykaf propaganda here though. Folks here should definitely read some Ray Peat articles to open up their minds. The "perceive, think, act" (or how I like it better: act, perceive, think) approach is crucial for sure; Together with giving insight on how corrupt our world is, demonstrating on some particular industries (food, medicine, science) You say he didn't live too long of a life, but you should consider that he was active throughout his whole life, always exploring and discovering, eating to his liking, no stressing for no reason, no wageslaving, etc ...

>>13165 I didn't mean to say he wasn't healthy. He was, he paid attention to his body and took care of it. I just meant that he didn't discover some secret about diet that let him live longer or achieve some biological feats. He led an interesting life and I've enjoyed reading his work. >>13163 Sugar is easily digestible carbohydrates. Which are the main source of energy for your body, especially the nervous system. They are also obligatory for proliferating cells which for adults is most obvious with the skin and other epithelial tissues and blood cells.

>>13164 >calories other sources exist >artificial sweeterners bad a reason to avoid fake sugar, not legitimization to chug sugar >>13166 easy way to get acne is consuming too much sugar.

>>13167 are we talking all sugar or just refined sugar or what here do you say honey is bad ? Fruit is bad? Starch that just digests quickly to sugar is bad? Just eat fat for your calories ?

>>13172 Fruit combines fructose with fiber, which causes the fructose to be processed in your gut. Where as added fructose in processed foods causes it to be processed in your stomach - very different. Refined sugar, aka sucrose, is a combination of glucose and fructose. In your stomach, it will be split, and the fructose be processed there, causing the same bad effects. With glucose from starch, there is a huge difference depending on the length of the glucose molecule. The body needs to break the molecule, which takes time if it is longer, therefore delivering more energy to your brain over time; while with shorter molecules, it is too much energy and the excessive amount gets stored as fat. You probably guessed it - long molecules are found in whole wheat bread, potatoes, etc. Short molecules in white bread etc.

>>13172 There are multiple aspects to this: 1. total sugar intake regardless of source you can get acne just eating a whole honey jar in one go, learned that by experience as a kid and repeated it to verify it was actually the cause Over consumption is possible even with healthy sources, so total sugar intake is important regardless of source 2. sugar form hfcs is worse than regular sugar because it bypasses how the body registers sugar intake traditional normal sugar is 1:1 glucose/fructose so body reliable worked registering fructose by only counting glucose with hfcs you get more fructose than glucose and the existing mechanism is blind to it 3. digestion Fruit cells trap the sugar, you digest about half the sugar contained eating fruit compared to drinking fruit juice. You can approach the problem from all these sides to reduce the damage but in essence it's all about reducing the effective dosage.

>>13174 i noticed the difference myself when i felt my blood sugar shootup far less and my teeth gather less plaque from greener bananas, or other fruit thats had less time to ripen and break up its own starch chains. >>13164 ive not had any bad experience with allulose, sucrose, stevia or monkfruit extracts, besides the majority of sugar-free/reduced goods tasting like sh!t. apartame however makes me feel like ass. that said, i think they enable people with bad habits to cheat around the mental training involved in breaking habits, which has obvious consequences should the cheating mechanism no longer be available. >>13167 this is totally true, emphasis on too much. eating two jumbo cookies during a heavy work shift on my feet lifting and jogging for 8 hours straight will cause me to develop zero acne. on the other hand, if i eat a couple pieces of candy while sedentary for an extended amount of time, i break out bad >>13163 im assuming you're singling out refined sugar, since nearly everything edible has an amount of sugar. in that case, it tastes good :) more seriously, they're a godsend for people like me whose blood sugar levels are tenuous, or those constantly moving and need quick sources of energy, though in that case, its best paired with fiber and protein, something like a sugary energy bar. another scenario is someone may suffer crohns disease with a stricture in the digestion tract, in that case, refined sugars can help maximize calories with less inflammation of the tract than complex carbs would cause as its digested far faster, spending less time hanging around the sensitive areas of the gut like fiber would.

Fatties discussing their inane dietary observations is hilarious. Eat less and exercise. Then you'll be able to metabolize sugar normally rather than blaming it for all your self-inflicted health problems. None of this is relevant to anti-aging. You won't age less with any meme diet that cuts out sugar or fats or meat or whatever. Otherwise we would have seen super long-lived yogic hermits or mongol steppe warriors long ago.

I can't believe this thread is almost 3 years old

>>13179 slight starvation has been proven to extend livespan in various animal studies. Diabetes 2 is also what happens if you eat like a animal. So there is evidence of food working on live span and over consumption leading to disease. And i see your motivation too: sugar addicte coping with bad news by lying to himself everyone is wrong and sugar is good!

>>13157 ketosis or fasting (autophagy states) have actually strong indicators for reducing inflammation, increasing insulin sensitivity and honing your metabolic health overall.

>>13111 There is more: by using one of the many modern methods to change the type of a cell, all age-related epigenetic errors can be removed; experiments with bioelectricity proved it's possible to order your cells to construct or fix any organ. Combining these 2 methods can give you a perfectly young, infertile female body made of perfectly young cells. Good luck.

>>13186 Over-consumption causes disease yes. Animals don't get diabetes when eating their natural diet. If you confine them and make them bored and give them too much food they will get diabetes. Same as how they become drug addicts if confined in a cage but not if they have sufficient area to explore and enough of a mouse social life. Slight starvation is not proven to extend lifespan because in practice it helps to fix the diet and activity levels or otherwise sick and bored lab mice. These findings didn't translate to monkeys or into epidemiological studies for humans. For humans you see a minor effect with very intense starvation (namely concentration camp survivors). For other species like fruit flies and worms you also need quite a severe caloric restriction to prolong lifespan. Basically you need to drop the energy levels enough that it slows the growth rate and reduces hormone levels, and you see a large reduction in fertility with it. I'm not a sugar addict... I like sweet stuff every once in a while, but I dislike the taste of added sugar to cooked meals or breads or such.

>>13253 >>13253 ironically, the opposite is true "calories restriction" biohack iz known as a way add some time to your clock

>>13269 If it was true then there would be evidence for it. People that live longer than expected because of calorie deficits. Which there aren't.

>>13248 I am very curious about this, i take an interest in such things and bio magnetism and biofeedback is rarely mentioned in the public sphere despite there being lots of research done into this. Considering how the human body is first and foremost an electrical system with most basic nutrients being used to replenish electric discrapencies in the system. Trauma likewise is an electric imbalance caused externally. As the body depends on electrical interactions any effect a single cell changes the charge and frenquency of the entire body. Since we can clone entire organism from a single cell it stands to reason that one can replace sick cells with new ones to repair damage. Likewise since genetic code is a pattern for reproduction of the entire organism by repairing genes one could live healthy indefinetly. I am very curious if anyone knows anything more specific, i try to do some research on this in the future, any pointers or hints could prove helpful.

>>13274 Giving orders to cells, in terms of practice, Michael Levin's experiments might be your best option. He was able to regenerate a limb in an animal that can't regenerate limbs, order animals to grow more eyes and tails and heads, even of a type their species can't normally grow, successfully order cancer cells to dismantle their tumor and get back to work... His method can't be used to order cells to turn into their initial progenitor, as far as I know, so it can't be used to reset age on its own… at least not yet; a necessary command might get discovered later.

>>13253 Your conclusion doesn't contradict the initial suggestion - like yes starvation is merely "fixing" a bad unnatural diet. Humans are an animal consuming a bad unnatural diet with a unnatural live style. Especially with processed foods that are high calorie and low macro nutrients. People are overeating on the trash food because they are starving in macro nutrients while growing fat due high calorie intake. Hybdridization and modern crops are commonly praised for higher yield but it comes at the cost of lower nutrients. Soil depledation is also only addressed on the level of providing the bare minimum plants need to grow. The moment they didnt label macro nutrients was the moment the battle was over. No quality control on what doesnt get measured. This is why you have various studies that show improvements with supplements. On topic one study showcased improving brain functionality in older people by merely feeding them multi vitamins. lastly fasting has the simple function of giving the body a break so it can flush soykaf out and repair better. Its simply helping you repair which naturally prevents greater issues down the line.

>>13317 Sure fasting is good for you and feels nice. But it won't make you live longer. No animal in the wild lives a longer time because it fasts, and no long lived humans exist because of fasting. The studies are artefacts of unhealthy lab animals with metabolic disorders, and so only applies to similarly sick humans. Sedentary, monotonous processed diet, and no independent will.

https://youtube.com/shorts/Vp6DCTB4rv8?si=LUHQVbtcyIWlmINs

>>11168 well it seems most like what contributes to aging is running out of stem cells or something else necessarry for reproduction of cells like rna or minerals basically you want to be able to grow back your organs and damaged tissues snd old tissues which means you should be injecting CLONED EMBRYOS or having ai manufacture a gland which you can attatch directly in place of another gland like tonsils or next to the blood its hard to write dna but if you told the ait to find the process which makes stem cells andjust invent a gland like a tiny kidney but he grow stem cells and the blood takes them away or something you can implant into a bone where the bone is storing stem cells for now

Anyone know what reverses white hair? I have a lot of white facial hair possibly from stress. This is only explanation since no one else in my family has white hair. While white hair can look cool having white facial hair has an aging look to it.